Oral ingestion of pomegranate extract reduces the production of chemicals that cause inflammation suggests a study published in BioMed Central’s open access Journal of Inflammation. The findings indicate that pomegranate extract may provide humans with relief of chronic inflammatory conditions.

The group from the Department of Medicine of Case Western Reserve University, Cleveland Ohio, led by Tariq Haqqi, showed that blood samples collected from rabbits fed pomegranate extract inhibited inflammation.

Pomegranate extract is already used as a treatment in alternative medicine for inflammatory conditions, such as arthritis. Although pomegranate extract has antioxidant and anti-inflammatory actions in experiments on isolated tissues, it is not known whether ingestion of it can produce the same anti-inflammatory effects in living systems, either because the active compounds are not absorbed from the gut or because the levels of these compounds in the blood are not high enough.

Pomegranate extract, the equivalent of 175mls of pomegranate juice, was given to rabbits orally. The levels of antioxidants were measured in blood samples obtained after drinking the pomegranate extract and compared to blood samples collected before ingestion of pomegranate extract.

Plasma collected from rabbits following ingestion of pomegranate extract contained significantly higher levels of antioxidants than samples collected before ingestion of pomegranate extract; the extract also significantly reduced the activity of proteins that cause inflammation, specifically cyclooxygenase-2. It also reduced the production of pro-inflammatory compounds produced by cells isolated from cartilage.

The results of this study indicate the beneficial effects of pomegranate extract when ingested. According to Haqqi “the use of dietary nutrients or drugs based on them as an adjunct in the treatment of chronic inflammatory conditions may benefit patients”. He adds that, “Current treatment with anti-inflammatory drugs can have serious side effects following long-term use. Further research is needed, however, especially on the absorption of orally ingested substances into the blood.”

A study from researchers at Children’s Hospital Boston published in Pediatrics found that a simple infection control intervention in elementary schools – disinfecting frequently-touched surfaces and using alcohol-based hand sanitizers – helped reduce illness-related student absenteeism.Illnesses caused by bacteria and viruses account for millions of lost school days each year.(1) According to Thomas Sandora, MD, MPH, a pediatric infectious diseases specialist at Children’s Hospital Boston, “The best ways to avoid common infections are cleaning your hands and preventing exposure to the germs that cause these illnesses. Our research indicates that elementary schools should consider a few simple infection control practices to help keep students healthier.”

The study, led by Dr. Sandora, was a randomized, controlled trial involving 285 third-, fourth-, and fifth-grade students in an elementary school system in Avon, Ohio. Teachers in intervention classrooms used disinfecting wipes on student desks, and students used hand sanitizer in the classroom at key points throughout the school day. Control classrooms followed usual hand washing and cleaning procedures.

Over eight weeks, researchers tracked the frequency of absences and the reasons for missing school. Study investigators also tested several classroom surfaces for total bacterial counts and for the presence of several common viruses.

Researchers found absenteeism rates for gastrointestinal illnesses were nine percent lower in classrooms that followed the infection control regimen of disinfecting surfaces and using alcohol-based hand sanitizers. The absenteeism rate for respiratory illness was not affected by this intervention.

Gastrointestinal illnesses are extremely common for school-age children, and children can be at risk for these infections because of frequent exposure to ill peers and poor hand hygiene.(1) In fact, the bacteria and viruses that cause these gastrointestinal infections can be easily passed from one person to another on the hands.(2) The germs can also survive on surfaces in the environment, where some of them can persist for hours to days.(1)

The study suggests that schools should consider adopting simple infection control practices, including disinfecting desktops once a day and using hand sanitizer before and after lunch, to help reduce days lost to common illnesses.

“From a basic science perspective, the advances being made in genomics are important discoveries, but it’s unrealistic for individuals to believe those advances can yield meaningful information that will improve their health,” said James P. Evans, M.D., Ph.D., professor of genetics and medicine in the UNC School of Medicine. “And even saying ‘It’s not there yet’ is too optimistic. It’s going to be a long time before the potential is realized.”

Evans, who is also the director of the cancer and adult genetics clinics and the Bryson Program in Human Genetics in UNC’s medical genetics department, will talk about how personal genomics will affect human lives at a panel discussion titled “Your Biological Biography” at the World Science Festival being held in New York City, May 28 to June 1. Evans will speak between 1 p.m. and 2:30 p.m. on Saturday, May 31, at the Kimmel Center for University Life at New York University.

“The sequencing of the human genome revealed that in relative terms, humans are 99.9 percent the same,” Evans said. “But in absolute terms, we are very different. For example, a one-thousandth of a difference in their respective DNA profiles translates into more than 3 million differences between any two unrelated individuals.”

Some of these differences are medically relevant, in that they influence disease predisposition and response to drugs, areas Evans studies in his research. And the differences are of interest in non-medical ways, specifically when they address ancestry, behavior traits and the innate curiosity humans have about their genes.

Sequencing of the human genome, which was completed in 2003, also gave rise to commercial entities offering direct-to-consumer genetic testing for a fee, usually between $1,000 and $3,000. Evans worries that individuals may seek such testing with the false hope that they will get meaningful results regarding their risks for disease and actionable medical advice about how to decrease their risks.

“Much of the current excitement about genetics and medical genomics is predicated on the idea that knowing our genomes better will improve our health,” Evans said. “In fact, for the vast majority of such risk assessments, the increased risk of an individual developing the disease in question is modest – one- to two-fold over baseline. And in few such conditions are there specific effective interventions to diminish the risk. Further, there is little evidence that having the specific genetic information would actually induce a change in lifestyle.”

Society has tended to place an almost mystical association on genetic information, Evans said, adding that what to do with this new knowledge and how to interpret the information presents many unanswered challenges.

“Most physicians, by their own admission, are not geneticists and won’t know what to do with the information,” said Evans, who uses family history and genetic testing to evaluate and counsel patients about their risk for cancer. “Many who do understand the technology and how it is generated don’t know what to do with it. So there’s huge potential for patient harm – either for patients to be lulled into a false sense of security by this new genomic information or, in the opposite extreme, to have unnecessarily increased anxiety.”

And Evans said he can see even more extreme measures “where interventions are implemented – for example, a total body scan – that put patients on a road to invasive tests that they are better off not getting.”

Evans believes these challenges say something about how humans value information, but then fail to scrutinize what it really means. “It’s hard for me to over-estimate the beauty and utter significance of sequencing the human genome and other animal genomes,” Evans said. “The technology is very promising for all of us, but there is a big gap between having that knowledge and applying it for the betterment of human health.”

Past research has found that patients enrolled in weight-management programs experience greater success as the frequency they meet with physicians or weight-loss counselors about their progress increases. The U.S. Preventative Services Task Force, an organization that recommends guidelines for primary care in the U.S, classifies two provider contacts with patients as intensive. A study by NiCole Keith, associate professor in the Department of Physical Education at Indiana University-Purdue University in Indianapolis, found that this current recommendation may not be intensive enough for low-income and disadvantaged populations.

Her study was conducted in an urban community health center in Indianapolis that primarily serves low-income and disadvantaged populations. The weight-management program, Take Charge Lite (TCL), was free to patients, funded by the Fairbanks Foundation and available to all patients 18 or older with a body mass index indicating they could be overweight or obese — equal to or above 25. The program was developed for English or Spanish-speaking patients and used input from physicians, administrators and patients of the clinic. If patients qualified, their physician gave them information about TCL and the program coach’s contact information. Once a patient phoned, a first visit was arranged at which the patient chose goals, weighed-in, and discussed different weight-loss strategies with the coach. Program participants could attend support groups, education or exercise classes, meet face-to-face with coaches, or have regular weigh-ins. Each of these activities qualified as a contact.

At the end of the program’s first year, the relationship between weight loss and number of contacts was evaluated. Patients with two or fewer contacts per month gained about a pound. Patients with three or four contacts per month lost about two pounds of weight and patients who had five contacts per month lost just over two pounds. Those with six or more contacts lost about five pounds and patients with more than 11 contacts per month lost about six pounds. Keith said the program will continue and that she’s optimistic about its impact. “TCL coaches helped patients find strategies tailored to patient needs and abilities to help with weight loss,” she said. “Indentifying factors associated with weight loss and program participation may improve weight loss services, maximize contact and lead to increased weight loss in this population.”

An Indiana University study involving college freshmen found that almost half of the students had at least two risk factors for heart disease. The study, led by Cameron L. Troxell, a graduate student in the IU Bloomington School of Health, Physical Education and Recreation, involved 101 male and female college freshmen who answered a questionnaire designed to help researchers gauge the students’ perceptions of their own health compared to the actual measurements. The study found that 30 percent of the students had high cholesterol, compared to 4 percent who self-reported this risk factor. “A lot of the students were very surprised that they had high cholesterol,” said co-author Jeanne Johnston, assistant professor in the School of HPER’s Department of Kinesiology. “It really hit home that they need to start thinking about their healthy habits and behaviors.” Johnston said the college-age population is an understudied age group but an important age group, because of the independence that occurs during this critical transition period and the potential for developing lifelong healthy habits.

Short-term exposure to low levels of particulate air pollution may increase the risk of stroke or mini-stroke, according to findings that suggest current exposure standards could be insufficient to protect the public.”The vast majority of the public is exposed to ambient air pollution at the levels observed in this community or greater every day, suggesting a potentially large public health impact,” said Lynda Lisabeth, lead author and assistant professor in the University of Michigan School of Public Health.

However, Lisabeth stressed that the association requires further study in other areas with varying climates and alternative study designs. Stroke is the third leading cause of death in the United States.

The study examined particulate air pollution in a southeast Texas community where there is a large petroleum and petrochemical industry presence. Particulate matter is one type of air pollution, defined as tiny particles of solid or liquid that can cause numerous health problems when inhaled. These particles can be man-made or from natural sources.

In the study, researchers identified ischemic strokes and transient ischemic attacks (TIA), sometimes called mini strokes but that often lead to a stroke later. Ischemic attacks are caused by a blockage of blood flow to the brain by a blood clot.

The results showed borderline significant associations between same day and previous day fine particulate matter exposures and ischemic stroke/TIA risk. Similar associations were also seen with ozone, another type of pollution. Despite the fossil fuel industry in the area, fine particulate matter exposures were low relative to other regions of the country, probably because of the proximity to the coast and prevailing wind patterns.

Findings suggest that recent exposure to fine particulate matter may increase the risk of ischemic cerebrovascular events specifically. Some research has shown that particulate air pollution is associated with acute artery vasoconstriction and with increased thickening of the blood, which may enhance the potential for blood clots. However, this requires further study.

Researchers looked at data from the Brain Attack Surveillance in Corpus Christi Project, a population-based stroke surveillance project designed to capture all strokes in Nueces County, Texas. Ischemic stroke and TIA cases between 2001 and 2005 were identified using trained staff and later verified by neurologists. Daily historical air pollutant and meteorological data were obtained for the same time period from the Texas Commission on Environmental Quality’s Monitoring Operations database. Data on fine particulate matter and ozone were available from a centrally located monitor in Corpus Christi, Tex., located upwind of the local industrial facilities. The majority of stroke/TIA cases were also located upwind of local chemical plants and refineries.

“Consumers who understand their emotional ability can make higher quality consumption decisions such as health decisions and product choices,” explain the authors, Blair Kidwell, David M. Hardesty, and Terry L. Childers (University of Kentucky). “A person can know a lot about nutrition and know what foods are not healthy, but can still make poor decisions when unable to recognize, reason, and solve problems based on emotional patterns,” they add. For example, compulsive eaters may understand nutrition, but they may not realize their emotions affect their food choices.This research establishes a new method for assessing consumers’ emotional intelligence. The authors developed a scale by testing undergraduates with more than 110 questions about emotions and consumption. As a result of this research, the authors were able to determine which emotion-related questions best predicted overeating.

The researchers then narrowed the questions to 18. They measured four different dimensions of consumer emotional ability: perceiving, facilitating, understanding, and managing emotions.  This 18-item scale—called the CEIS, or Consumer Emotional Intelligence Scale—is a highly reliable indicator of consumer behavior.

It seems consumers who care about healthy eating need to consider their feelings instead of studying nutrition labels.