Women who took beta carotene or vitamin C or E or a combination of the supplements had a similar risk of cancer as women who did not take the supplements, according to data from a randomized controlled trial in the December 30 online issue of the Journal of the National Cancer Institute.

Epidemiological studies have suggested that people whose diets are high in fruits and vegetables, and thus antioxidants, may have a lower risk of cancer.  Results from randomized trials that address the issue, however, have been inconsistent and have rarely supported that observation.

In the current study, Jennifer Lin, Ph.D., of the Brigham and Women’s Hospital and Harvard Medical School in Boston, and colleagues tested the impact of antioxidant supplements on cancer incidence in a randomized controlled trial.  A total of 7,627 women who were at high risk of cardiovascular disease were randomly assigned to take vitamin C, vitamin E, or beta-carotene.

With an average of 9.4 years of follow-up time, there was no statistically significant benefit from antioxidant use compared with placebo in terms of disease risk or mortality due to cancer.  Overall, 624 women developed cancer and 176 died from cancer during the follow-up time.  Compared with placebo, the relative risk of a new cancer diagnosis was 1.11 for women who took vitamin C, 0.93 for women who took vitamin E, and 1.00 for women who took beta carotene.  None of these relative risks was statistically significantly different from 1.

“Supplementation with vitamin C, vitamin E, or beta carotene offers no overall benefits in the primary prevention of total cancer incidence or cancer mortality,” the authors conclude.  “In our trial, neither duration of treatment nor combination of the three antioxidant supplements had effects on overall fatal or nonfatal cancer events.  Thus, our results are in agreement with a recent review of randomized trials indicating that total mortality was not affected by duration of supplementation and single or combined antioxidant regimens.”

In an accompanying editorial, Demetrius Albanes, M.D., of the National Cancer Institute, reviewed data from previous randomized controlled trials that examined supplement use and cancer incidence.  He noted that while the trial data reported by Lin are negative with respect to lowering cancer risk, there is valuable information uncovered that should not be overlooked.  There was a trend for a reduction in colon cancer with vitamin E supplementation, which has been observed in other studies.  Additionally, beta carotene use was associated with a modest excess of lung cancer, which is consistent with previous reports.

“Null trials or those with unexpected outcomes should not, however, be viewed as failures; they have and will con¬tinue to shed light on the causes of cancer and help us discover the means for its prevention,” the editorialist concludes.

New research in an animal model suggests that a diet high in inorganic phosphates, which are found in a variety of processed foods including meats, cheeses, beverages, and bakery products, might speed growth of lung cancer tumors and may even contribute to the development of those tumors in individuals predisposed to the disease.

The study also suggests that dietary regulation of inorganic phosphates may play an important role in lung cancer treatment.  The research, using a mouse model, was conducted by Myung-Haing Cho, D.V.M., Ph.D., and his colleagues at Seoul National University, appears in the first issue for January of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

“Our study indicates that increased intake of inorganic phosphates strongly stimulates lung cancer development in mice, and suggests that dietary regulation of inorganic phosphates may be critical for lung cancer treatment as well as prevention,” said Dr. Cho.

Lung cancer is the number one cause of cancer deaths in the world and is also the most frequently diagnosed solid tumor.  Non–small cell lung cancer (NSCLC) constitutes over 75 percent of lung cancers and has an average overall 35-year survival rate of 14 percent.  Earlier studies have indicated that approximately 90 percent of NSCLC cases were associated with activation of certain signaling pathways in lung tissue.  This study revealed that high levels of inorganic phosphates can stimulate those same pathways.

“Lung cancer is a disease of uncontrolled cell proliferation in lung tissue, and disruption of signaling pathways in those tissues can confer a normal cell with malignant properties,” Dr. Cho explained.  “Deregulation of only a small set of pathways can confer a normal cell with malignant properties, and these pathways are regulated in response to nutrient availability and, consequently, cell proliferation and growth.

“Phosphate is an essential nutrient to living organisms, and can activate some signals,” he added.  “This study demonstrates that high intake of inorganic phosphates may strongly stimulate lung cancer development by altering those (signaling) pathways.”

In the study, lung cancer-model mice were studied for four weeks and were randomly assigned to receive a diet of either 0.5 or 1.0 percent phosphate, a range roughly equivalent to modern human diets.  At the end of the four-week period, the lung tissue was analyzed to determine the effects of the inorganic phosphates on tumors.

“Our results clearly demonstrated that the diet higher in inorganic phosphates caused an increase in the size of the tumors and stimulated growth of the tumors,” Dr. Cho said.

Dr. Cho noted that while a moderate level of phosphate plays an essential role in living organisms, the rapidly increasing use of phosphates as a food additive has resulted in significantly higher levels in average daily diets.  Phosphates are added to many food products to increase water retention and improve food texture.

“In the 1990s, phosphorous-containing food additives contributed an estimated 470 mg per day to the average daily adult diet,” he said.  “However, phosphates are currently being added much more frequently to a large number of processed foods, including meats, cheeses, beverages, and bakery products.  As a result, depending on individual food choices, phosphorous intake could be increased by as much as 1000 mg per day.”

“Although the 0.5 percent was defined as close to ‘normal,’ the average diet today is actually closer to the one percent diet and may actually exceed it,” Dr. Cho noted.  “Therefore, the 0.5 percent intake level is actually a reduced phosphate diet by today’s scale.”

Dr. Cho said future studies will help refine what constitutes a “safe” level of dietary inorganic phosphate, with recommendations that will be easily achievable in the average population.

“The results of this study suggest that dietary regulation of inorganic phosphates has a place in lung cancer treatment, and our eventual goal is to collect sufficient information to accurately assess the risk of these phosphates,” he said.

John Heffner, M.D., past president of the ATS, stated that this line of investigation in animals addresses the complex interactions between host factors and the environment that underlie cancer in man.  “We know that only some patients who smoke develop lung cancer but the reasons for this varying risk are unknown.  This study now provides a rationale for funding case-control studies in humans to determine the potential role of dietary phosphates in promoting cancer.”

About 5 million people in the United States suffer from heart failure (HF). While some reports indicate that changes to diet can reduce HF risk, few large, prospective studies have been conducted. In a new study researchers observed over 14,000 participants for more than 13 years and found that whole grain consumption lowered HF risk, while egg and high-fat dairy consumption raised risk. Other food groups did not directly affect HF risk. The results are published in the November 2008 issue of the Journal of the American Dietetic Association.Diet is among the prominent lifestyle factors that influence major HF risk factors: coronary artery disease, obesity, diabetes and insulin resistance and hypertension. Using data from the Atherosclerosis Risk in Communities (ARIC) study, researchers from the Division of Epidemiology and Community Health, University of Minnesota and the Department of Epidemiology and Cardiovascular Diseases Program, University of North Carolina, analyzed the results of baseline exams of more than 14,000 White and African American adults conducted in 1987-89, with follow-up exams completed during 1990-92, 1993-95, and 1996-98. Four field centers participated in the study: Forsyth County, NC; Jackson, MS; northwest Minneapolis suburbs, MN; and Washington County, MD. The study also collected demographic characteristics and lifestyle factors, as well as other medical conditions such as cardiovascular disease, diabetes and hypertension.

Writing in the article, Jennifer A. Nettleton, Ph.D., states, “Although risk estimates were modest (7% lower risk per 1-serving increase in whole grain intake; 8% greater risk per 1-serving increase in high-fat dairy intake; 23% greater risk per 1-serving increase in egg intake), the totality of literature in this area suggests it would be prudent to recommend that those at high risk of HF increase their intake of whole grains and reduce intake of high-fat dairy and eggs, along with following other healthful dietary practices consistent with those recommended by the American Heart Association.”

A nutritious diet is not seen as being as important as physical activity when it comes to college students’ health and wellness efforts, according to Indiana University researchers, even when the students live in an environment that provides classes, cues and motivation to eat healthily. “Personal preferences triumph over discipline,” the researchers note. The researchers examined the eating habits of college students as they transitioned from high school to university life and to living in residence halls or apartments. Habits that college students establish as they leave home may have long-reaching effects on their health and that of their future families, the researchers note. The students, they say, bring to college the eating habits established at home, where most skipped breakfast and almost 40 percent ate out for dinner or were on their own. This “grab and go” view of food and a preference for restaurant-style foods was apparent in the study. Researchers found that regardless of the variety available in the residence hall or the need to prepare meals in apartment living, foods that can require more preparation or are more perishable are eaten less often. The researchers studied three groups of students — students in apartments, students living in a residence hall and students living in a Fitness and Wellness Living-Learning Center, a themed residential community that provides students with an onsite fitness facility and educational material — including a required course on healthy living. Students in all three groups achieved similar levels of physical activity, with around 56 percent meeting the recommended three bouts of exercise weekly. Compared to how they ate at home, the students reported eating the same amount or less of the healthy foods examined. Students in the Living and Learning Center reported eating even less of these healthy foods. The findings suggest that school and college health educators should consider providing students with tools to “internalize that fitness = exercise = healthy food,” and to find ways for them to eat healthy in our grab-and-go world.

Soybeans may drop off the list of musical fruit. Scientists in Singapore are reporting victory over some consumers’ No. 1 complaint about soy products — the “flatulence factor” caused by indigestible sugars found in soy. In a study scheduled for the November 12 issue of ACS’ bi-weekly Journal of Agricultural and Food Chemistry, they describe a method for significantly reducing the amount of flatulence-causing carbohydrates in soy yogurt while raising the levels of healthy antioxidants known as isoflavones.

In the study, Dejian Huang and colleagues note that soy yogurt has a global market share of only 1.9 percent, even though it has a number of health advantages over dairy-based yogurt. That’s partly because of the flatulence-causing compounds in soy. “It would be desirable to remove the flatulence-causing raffinose and stachyose from the soy yogurt to improve consumers’ preferences. The objective of this study was to develop a new soy yogurt enriched with isoflavones with reduced levels of flatulence-causing oligosaccharides,” the scientists said.

The researchers grew soybeans in the presence of a fungus that produced enzymes capable of degrading the undesired sugars. “We have demonstrated for the first time that germinated black soybeans under fungal stress can be fermented into a soy yogurt which features a low amount of flatulence-causing oligosaccharides but with a significant level of isoflavones,” says Huang.

Making vegetable juice a daily habit could be a small step that can lead to big changes in meeting daily vegetable recommendations, according to a new study being presented by researchers from the University of California-Davis this week at the American Dietetic Association annual conference1.

With seven out of 10 adults falling short of the daily recommended vegetable intake as put forth by the U.S. Dietary Guidelines, researchers studied whether drinking vegetable juice could be a simple behavior change to help boost the intake of this critical food group2.  And it was.

The study looked at three groups of healthy men and women.  All three groups received dietary counseling on ways to get more vegetables, but only two of the groups were instructed to consume at least one serving of vegetable juice, in the form of V8® 100% vegetable juice each day.  Of those two groups, one drank one 8-ounce glass of vegetable juice every day and the other drank two 8-ounce glasses of vegetable juice every day as part of a balanced eating plan.

The study found that those who received dietary counseling and consumed vegetable juice were far more likely to meet the daily vegetable recommendations, about two and a half cups (five servings), than those who received counseling alone.  Specifically, more than half of the participants who drank one serving of V8 100% vegetable juice met the recommendations, as did all of those who drank two 8-ounce glasses of V8 100% vegetable juice each day.  Of those who did not drink any vegetable juice, less than a quarter got enough vegetables.

Researchers concluded that changing dietary behavior is much more effective when dietary advice is complemented with tangible, real, easy and convenient solutions.

“What we found in this study is that drinking vegetable juice seemed to address some of the key barriers to vegetable consumption such as convenience, portability and taste, so individuals were more likely to meet their daily recommendations,” said Carl Keen, PhD, study author and distinguished Professor of Nutrition & Internal Medicine at University of California, Davis.  “Furthermore, vegetable juice drinkers reported that they actually enjoyed drinking their vegetables, which is critical to adopting dietary practices for the long-term.”

In fact, after six weeks of the study, vegetable drinkers reported they felt “more satisfied” with the ease of getting vegetables into their diet, and that V8 100% vegetable juice provided an important additional source of vitamins and minerals.

Experts Agree

A growing body of science indicates vegetables are important to promoting good health, including helping to reduce risk factors for heart disease, diabetes and achieving a healthy weight.  According to Produce For Better Health, all forms count.

“The best type of vegetable is one that you will actually consume, so it’s important to provide people with a variety of great tasting options and ways to include them in their diet,” said Elizabeth Pivonka, PhD, RD, Produce for Better Health Foundation.  “That’s why we encourage people to explore all types of vegetables, such as 100% juice, fresh, frozen or canned, to get at least one serving of vegetables at each meal occasion throughout the day.”

Moderate consumption of red wine may decrease the risk of lung cancer in men, according to a report in the October issue of Cancer Epidemiology, Biomarkers & Prevention¸ a journal of the American Association for Cancer Research.

“An antioxidant component in red wine may be protective of lung cancer, particularly among smokers,” said Chun Chao, Ph.D., a research scientist at Kaiser Permanente Department of Research and Evaluation in Pasadena, California.

Chao analyzed data collected through the California Men’s Health Study, which linked clinical data from California’s health system with self-reported data from 84,170 men aged 45 to 69 years. Researchers obtained demographics and lifestyle data from surveys computed between 2000 and 2003, and identified 210 cases of lung cancer.

Researchers measured the effect of beer, red wine, white wine and liquor consumption on the risk of lung cancer. Adjustments were made for age, race/ethnicity, education, income, body mass index, history of chronic obstructive pulmonary disease or emphysema, and smoking history.

Among the study participants, there was on average a two percent lower lung cancer risk associated with each glass of red wine consumed per month. The most substantial risk reduction was among smokers who drank one to two glasses of red wine per day. The researchers reported a 60 percent reduced lung cancer risk in these men. Researchers warned men to stop smoking as the best way to reduce lung cancer risk; noting that even men who drank one to two glasses of red wine per day still face higher lung cancer risk than do non-smokers.

No clear associations with lung cancer were noted for consumption of white wine, beer, or liquor. “Red wine is known to contain high levels of antioxidants. There is a compound called resveratrol that is very rich in red wine because it is derived from the grape skin. This compound has shown significant health benefits in preclinical studies,” Chao said.

Chao said their findings should not be construed to recommend heavy alcohol consumption.

A fatty acid found in abundance in olive oil and other “healthy” unsaturated fats has yet another benefit: it helps keep the body satisfied to prolong the time between meals.

A new study in the October Cell Metabolism, a publication of Cell Press, reveals that once this type of fat, known as oleic acid, reaches the intestine, it is converted into a lipid hormone (oleoylethanolamide, or OEA) that wards off the next round of hunger pangs.  The researchers said it may be the first description of an ingredient in food that directly provides the raw materials for a hormone’s production.

The findings in rats may yield insight into the precise dietary makeup of fat and protein for optimal hunger control, the researchers said.  (Protein plays in important role in limiting hunger as well, but by different means.)  The newly discovered signaling pathway might also be tapped into with drugs designed to control appetite by supplementing OEA levels or blocking its breakdown.  Similarly, in conditions where people don’t eat enough, the researchers speculate that treatments targeting this system might improve the appetite.

Importantly, diets high in processed foods that are riddled with saturated fats might throw a wrench into this system of metabolic control, the researchers said.

” Eating is one of the most important things animals do,” said Daniele Piomelli of the University of California, Irvine.  “This is just one of many things that control it.  That said, a system like this could be forced to inactivation by inappropriate feeding,” he said, noting that saturated fats generally lack in oleic acid.

While such diets may lead people to overeat, Piomelli said it will also be of interest to see if this mechanism may be defective in some who tend to eat in excess.

Previous studies had shown that feeding stimulates cells in the intestinal lining to produce OEA, which, when administered as a drug, decreases meal frequency by engaging receptors called peroxisome proliferator-activated receptors a (PPARa).

Piomelli’s team now reports that infusion of fat into the small intestine stimulates the release of OEA, whereas infusion of protein or carbohydrate does not.  They also demonstrate that OEA production uses dietary oleic acid and is disrupted in mutant mice lacking the membrane fatty-acid transporter CD36.  Treatments that disrupt CD36 or PPARa undermine the hunger control otherwise driven by fat.

Overall, the results suggest that activation of small-intestinal OEA release, enabled by CD36-mediated uptake of oleic acid from the diet, serves as a molecular sensor linking fat consumption to satiety.  (Piomelli said satiety is perhaps best described as the opposite of hunger.)

” In conclusion,” the researchers wrote, “our studies identify OEA as a key physiological signal that specifically links dietary fat ingestion to across-meal satiety.  Nutritional and pharmacological strategies aimed at magnifying this lipid-sensing mechanism, such as inhibitors of OEA degradation, might be useful in the treatment of obesity and other eating disorders.”

A Brazilian palm berry sweeping the globe as a popular health food though little research has been done on it – now may have its purported benefits better understood.

In the first research involving people, the acai (ah-sigh-EE) berry has proven its ability to be absorbed in the human body when consumed both as juice and pulp.  That finding, by a team of Texas AgriLife Research scientists, was published in a recent issue of the Journal of Agricultural and Food Chemistry.

Showing the berry’s absorption in humans is important because it is known to contain numerous antioxidants.  The berry is heavily marketed in the U.S. as a health food.

The study involved 12 healthy volunteers who consumed a single serving of acai juice or pulp.  Researchers believe the results point to the need for continued research on the berry which is commonly used in juices, beverages, smoothies, frozen treats and dietary supplements.

“Acai is naturally low in sugar, and the flavor is described as a mixture of red wine and chocolate,” said lead investigator Dr. Susanne Talcott, “so what more would you want from a fruit?”

Talcott, who also is assistant professor with the Texas A&M University’s nutrition and food science department, said that previous studies have shown the ability of the human body to absorb target antioxidants (from other produce), but “no one had really tested to see if acai antioxidants are absorbed in humans.”

Sales of acai products have increased dramatically in the U.S. where it has been touted as a metabolism booster, weight reducer and athletic enhancer.  Advertisements use buzzwords such as health, wellness, energy, taste and organic.

About the only buzzword not used with acai is “local.”  The berries are harvested in the Brazilian rainforest from acai palms that may reach heights in excess of 60 feet one of the same palms used to harvest edible hearts of palm.

The fruit is about the size of a large blueberry yet only the outermost layers of the fruit, the pulp surrounding a large internal seed, are edible, Talcott noted.

Talcott and her co-researcher and husband Dr. Steve Talcott began studying the palmberry in 2001.  His first scientific report on acai, apparently the first such study in English, was published in 2004.

Initially, their studies on the berry examined antioxidant and nutritional components in pulp and juice.  Later studies showed the berry’s activity against cancer cells, Talcott noted.

With that background, the researchers then decided to find out whether those elements were actually being absorbed into the human body or being eliminated unused as waste.

“Like vitamin C, the body can only absorb so much at a time,” Steve Talcott explained.

He said the researchers now “need to determine potential disease-fighting health benefits, so we can make intelligent recommendations on how much acai should be consumed.

For the clinical trial, people were given acai pulp and acai juice containing half the concentration of anthocyanins as the pulp and each compared to the control foods: applesauce and a non-antioxidant beverage.

Blood and urine samples at 12 and 24 hours after consumption showed significant increases in antioxidant activity in the blood after both the acai pulp and applesauce consumption, she said.  Both acai pulp and acai juice showed significant absorption of antioxidant anthocyanins into the blood and antioxidant effects.  The research couple said future studies hopefully will help determine whether the consumption of acai will result in any disease-preventing health benefit and the proper serving sizes for a beneficial dose for people.

“Our concern has been that it is sold as a super food – and it definitely has some good attributes – but it is not a solution to all diseases,” she said.  “There are a great number of foods on the market, and this could just be part of a well-balanced diet.”

If the current financial climate has taught us anything, it’s that a system where over-borrowing goes unchecked eventually ends in disaster.  It turns out this rule applies as much to our bodies as it does to economics.  Instead of cash, our body deals in energy borrowed from muscle and given to the brain.

Unlike freewheeling financial markets, the lending process in the body is under strict regulation to ensure that more isn’t lent than can be afforded.  New research by scientists at the Salk Institute for Biological Studies reveals just how this process is implemented.

“We have all seen the sub-prime mortgage crisis,” says Marc Montminy, M.D., Ph.D., a professor in the Clayton Foundation Laboratories for Peptide Biology who led the current study.  “If you take out a loan, sooner or later you’ve got to pay your debt, and the same is true in fasting metabolism.”

The Salk researchers’ findings, which are published ahead of print in the Oct. 5 edition of the journal Nature, may pave the way for novel therapies for sufferers of metabolic diseases in whom such regulation can spiral out of control.

Most tissues in our bodies respond to fasting by switching from their usual high-octane energy source—glucose—to burning a low-octane, cheaper alternative-fat.  For our brains, however, only the high-performance fuel will do.  If no food-derived glucose is available, the body must manufacture its own supply to maintain the brain in the manner to which it is accustomed.  It does so by taking energy from muscle in the form of protein and converting it to glucose in the liver, a process known as gluconeogenesis.  The sugar is then shipped via the bloodstream to the brain to keep it running smoothly.

Gluconeogenesis needs to be turned on rapidly in response to fasting, but shutting it off again is just as crucial.  “You don’t want gluconeogenesis to be prolonged,” says postdoctoral researcher and co-first author Yi Liu, Ph.D. “Because it uses muscle as a protein source, it will eventually lead to muscle wastage.”  Adds Montminy, “The question has always been how is the production of glucose turned on, and how is shut off again?”

Previous work by the Montminy lab and others has shown that two key proteins, CRTC2 and FOXO1, are needed to turn on glucose-making genes during fasting.  CRTC2 is activated by glucagon, a hormone whose levels go up when we stop eating.  FOXO1, on the other hand, is activated when levels of the food-stimulated hormone insulin drop below a certain threshold.  CRTC2’s and FOXO1’s activity needs to be tightly regulated, since producing too much glucose would result in over-borrowing of energy from muscle tissue.

To uncover the mechanism that ensures that this doesn’t happen, the Salk researchers created mice containing the gene for luciferase, a light-emitting enzyme usually found in fireflies, engineered in such a way that it was only turned on when CRTC2 was active.  Using imaging equipment, they could then detect CRTC2 activity in the livers of live mice simply by measuring how much they glowed.

When the mice were fasted, CRTC2 was rapidly activated, and the livers lit up, but to the scientists’ surprise, after six hours the light went out.  Experimentally decreasing the levels of CRTC2 or FOXO1 confirmed there was a two-stage fasting-response.  Lowering CRTC2 reduced gluconeogenesis only early on, while less FOXO1 only affected late glucose production.  As in a relay race, during fasting the baton for glucose production appeared to be passed from CRTC2 in stage one to FOXO1 in stage two.

The crucial switch from CRTC2 to FOXO1 comes in the form of SIRT1, a nutrient sensor that accumulates in the late fasting stage.  Yi discovered that SIRT1 has opposite effects on CRTC2 and FOXO1: it sends the former to the recycling bin, while it activates the latter, and thus the baton is safely transferred from CRTC2 to the FOXO1.

Why does the body want to change between these two regulators of glucose production?  Again, it comes down to body economics.  CRTC2 acts as a rapid response unit to quickly produce high levels of glucose when it detects glucagon.  Switching to FOXO1 later on slows down this production to more sustainable levels, while at the same time helping to produce ketone bodies, an alternative fuel the brain can use that does not require taking protein from muscle.  “It is just like paying your loan back,” says Montminy.  “Later on you produce blood sugar at a different rate than you did at the beginning.”

Knowledge of how this nutrient switch is working may help design new drugs to regulate sugar levels in diabetes patients.  In, particular, chemical activators of the SIRT1 switch may be key.  “This way we could provide control for patients with insulin resistance,” says Montminy, “as typically their blood sugars are elevated after overnight fasting because the switches that regulate the glucose-producing enzymes are too active.”  Perhaps, then, a pharmacological rescue package for patients whose lending systems have been left unregulated may be on the horizon.

America does a mediocre job caring for its sickest people.  The nation, says a new report, gets a C.

Palliative care programs make patients facing serious and chronic illness more comfortable by alleviating their pain and symptoms and counseling patients and their families.

Only Vermont, Montana and New Hampshire earned an A, according to America’s Care of Serious Illness: A State-by-State Report Card on Access to Palliative Care in Our Nation’s Hospitals, a report based on a study in the October 2008 issue of the Journal of Palliative Medicine.  Three states – Oklahoma, Alabama and Mississippi – got an F.

“The good news is that hospitals nationwide have implemented palliative care programs quickly over the last six years,” said R. Sean Morrison, MD, director of the non-profit National Palliative Care Research Center and senior author of the study.  “The bad news is that if you live in the South or you have to rely on public or small community hospitals, you’re in trouble.”

Ninety million Americans are living with serious illnesses such as cancer, heart disease, diabetes, Parkinson’s, stroke and Alzheimer’s.  As the baby boomers age, this number will more than double over the next 25 years.

“Americans are living longer – but with serious illnesses,” said Dr. Diane E. Meier, director of the Center to Advance Palliative Care and co-author of the study.  “Without palliative care, people with serious illnesses like cancer often suffer unnecessarily from severe fatigue, pain, shortness of breath, nausea and other symptoms from their disease and treatments.”

The study suggests that in states with more palliative care programs, patients are less likely to die in the hospital; don’t have to go to the intensive care unit as much in the last six months of life; and spend fewer days in intensive care or the coronary unit in the last six months.

That also saves hospitals money, which could help lower health care costs.

When dining at Chinese Buffets, overweight individuals serve themselves and eat differently than normal weight individuals.  This may lead them to overeat, according to a recent study by Cornell University’s Food and Brand Lab.  Compared to normal weight diners, overweight individuals sat 16 feet closer to the buffet, faced the food, used larger plates, ate with forks instead of chopsticks, and served themselves immediately instead of browsing the buffet.

“What’s crazy is that these people are generally unaware of what they’re doing – they’re unaware of sitting closer, facing the food, chewing less, and so on,” say Brian Wanink, lead author of this study and of the book “Mindless Eating: Why We Eat More Than We Think.”

The study was published in the journal Obesity and includes observations of 213 diners at 11 all-you-can-eat Chinese restaurant buffets across the country.  Study participants included a range of normal weight to obese diners, none of whom were Asian.  Major study findings include:

* 27% of normal-weight patrons faced the buffet compared to 42% of obese diners.

* Overweight diners sat an average of 16 feet closer than normal-weight diners.

* 16% of obese diners sat at a booth rather than a table compared to 38% of normal weight diners

* 71% of normal-weight diners browsed the buffet before serving themselves compared to 33% of obese diners

* 24% of normal-weight people used chopsticks compared with 9% of overweight people

“When food is more convenient people tend to eat more,” say coauthor Collin R. Payne, New Mexico State University.

“These seemingly subtle differences in behavior and environment may cause people to overeat without even realizing it.”

An overload of calories throws critical portions of the brain out of whack, reveals a study in the October 3rd issue of the journal Cell, a Cell Press publication.  That response in the brain’s hypothalamus—the “headquarters” for maintaining energy balance—can happen even in the absence of any weight gain, according to the new studies in mice.

The brain response involves a molecular player, called IKKß/NF-?B, which is known to drive metabolic inflammation in other body tissues.  The discovery suggests that treatments designed to block this pathway in the brain might fight the ever-increasing spread of obesity and related diseases, including diabetes and heart disease.

“This pathway is usually present but inactive in the brain,” said Dongsheng Cai of the University of Wisconsin-Madison.  Cai said he isn’t sure exactly why IKKß/NF-?B is there and ready to spring into action in the brain.  He speculates it may have been an important element for innate immunity, the body’s first line of defense against pathogenic invaders, at some time in the distant past.

” In today’s society, this pathway is mobilized by a different environmental challenge—overnutrition,” he said.  Once activated, “the pathway leads to a number of dysfunctions, including resistance to insulin and leptin,” both important metabolic hormones.

Earlier studies showed that overnutrition can spark inflammatory responses in the peripheral metabolic tissues, including the muscles and liver, and therefore cause various metabolic defects in those tissues that underlie type 2 diabetes.  As a result, scientists identified IKKß as a target for an anti-inflammatory therapy that was effective against obesity-associated diabetes.

Yet whether metabolic inflammation and its mediators played a role in the central nervous system remained uncertain.  Now, the researchers show that a chronic high-fat diet doubles the activity of this inflammatory pathway in the brains of mice.  Its activity is also much higher in the brains of mice who are genetically predisposed to obesity, they found.

The researchers report that that increased activity of the IKKß/NF-?B pathway can be divorced from obesity itself -infusions of either glucose or fat into the brains of mice alone led to this inflammatory brain reaction.

Further studies revealed that this activity in the brain leads to insulin and leptin resistance.  Insulin lowers blood sugar by causing cells of the body to take it up from the bloodstream.  Leptin is a fat hormone important for appetite control.

Moreover, the researchers found that treatments preventing the activity of IKKß/NF-?B in the animals’ brains protected them from obesity.

While chronic inflammation is generally considered a consequence of obesity, the new results suggest the inflammatory reaction might also be a cause of the imbalance that leads to obesity and associated diseases, including diabetes.  As Cai says, it appears that inflammation and obesity are “quite intertwined.”  An abundance of calories itself promotes inflammation, while obesity also feeds back to the neurons to further promote inflammation in a kind of vicious cycle.

The findings could lead to treatments that might stop this cycle before it gets started.

“Our work marks an initial attempt to study whether inhibiting an innate immune pathway in the hypothalamus could help to calibrate the set point of nutritional balance and therefore aid in counteracting energy imbalance and diseases induced by overnutrition,” the researchers said.  “We recognize that the significance of this strategy has yet to be realized in clinical practice; currently, most anti-inflammatory therapies have limited direct effects on IKKß/NF-?B and limited capacity to be concentrated in the central nervous system.  Nonetheless, our discoveries offer potential for treating these serious diseases.”

If realized, such a strategy would likely offer a safe approach given that the critical pathway appears to be unnecessary in the hypothalamus under normal circumstances, they noted.

A carefully framed combination of moderate exercise and nutritional supplements could help older people maintain an active lifestyle for longer.

A Manchester Metropolitan University study has found that taking carbohydrate and protein supplements just before and just after low-resistance exercise could boost muscle performance and slow muscle wastage in people over retirement age.

Moreover, this combination appears to deliver greater fitness benefits than undertaking heavy-resistance training with or without changing one’s nutritional habits.

This was the first-ever study of the combination of structured exercise and nutritional supplements to focus wholly on older people.  Undertaken as part of the SPARC (Strategic Promotion of Ageing Research Capacity) initiative, the findings will be discussed at this year’s BA Festival of Science in Liverpool on Thursday 11th September.  SPARC is supported by the Engineering and Physical Sciences Research Council (EPSRC) and the Biotechnology and Biological Sciences Research Council (BBSRC).

This groundbreaking study involved a carefully selected sample of around 60 healthy, independent-living adults aged 65 and over.

The volunteers were randomly divided into groups who underwent different 12 week programmes of physical exercise and nutritional supplementation.  Everyone was then re-assessed at the end of the programme.

Some groups undertook low-resistance exercise once a week; others undertook high-resistance exercise twice a week.  Within each group, some of the volunteers took protein and carbohydrate supplements while others did not.

When all the participants were re-assessed at the end of the 12 week programme, it was observed that muscle size and strength had increased in all groups.

However, the results suggested that older people would derive the most benefits if they took appropriate supplements coupled with low-intensity exercise.

“Maintaining muscle performance and arresting muscle wastage can offer older people real improvements in their quality of life,” says Dr Gladys Pearson, who led the research.  “Though we still need to assess precisely what level of exercise gives the best results, we believe we’ve shown that regular low-resistance exercise complemented by the right nutritional supplements could boost the well-being of the UK’s ageing population.”

Dr Pearson and her team now aim to look at the effectiveness of novel combinations of strength training and nutritional supplementation as a way of speeding recovery and improving mobility for old and young orthopaedic surgery patients.

However much the likes of Jamie Oliver or Gordon Ramsay might want to shake up our diets, culinary evolution dictates that our cultural cuisines remain little changed as generations move on, shows new research, published today, Thursday, 10 July, 2008, in the Institute of Physics (IOP)’s New Journal of Physics (NJP).

The research, ‘The non-equilibrium nature of culinary evolution’, shows that three national cuisines British, French and Brazilian – are affected by the founder effect which keeps idiosyncratic and nutritionally ambivalent, expensive and sometimes hard to transport ingredients in our diets.

Using the medieval cookery book, Pleyn Delit, and three authoritative cook books from Britain, France and Brazil, the New Penguin Cookery Book, Larousse Gastronomique and Dona Benta respectively, the researchers from the University of Sao Paulo, Brazil, compiled statistics which could be compared to see how time and distance effect the three different national cuisines.

Time, the number of ingredients used, the number of recipes published in each cook book and the ratio between the number of ingredients and the number of recipes in the books were used as variables to assess how our diets have evolved.

Three editions of Dona Benta, from 1946, 1969 and 2004, were evaluated to see how the Brazilian diet has changed over the past half century, amidst the change from a regional to a more globalised food consumer profile, and found that the rank and importance of certain idiosyncratic ingredients, such as chayote, an edible plant that is a frequent ingredient in Central and South American diets, remained much the same.

Ranking the importance of certain food types by their frequency of use in each national cuisine and comparing them to ingredients which have an equivalent rank in one of the other two foreign cuisines led to patterns emerging which suggest that all our menus evolve in similar ways.

So, whether it’s the Irish with potatoes, the French with frogs’ legs, the Germans with sauerkraut, the Ghanaians with plantains or the Japanese with fish stock, it seems a global food culture has not shifted some die-hard culture-based eating habits.

As the authors, from the Department of Physics and Mathematics at Sao Paulo University, write, “Some low fitness ingredients present in the initial recipes have a strong difficulty of being replaced and can even propagate during culinary growth.  They are like frozen “cultural” accidents.”