ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions.

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Abstract Text:

Chen-Yu Bai,Miho Ohsugi,Yoshinori Abe,Tadashi Yamamoto,

Focal adhesion protein ZRP-1/TRIP6 has been implicated in actin reorganization and cell motility. The role of ZRP-1, however, remained obscure because previously reported data are often conflicting one another. In the present study, we examined roles of ZRP-1 in HeLa cells. ZRP-1 is localized to the cell-cell contact sites as well as to cell-matrix contact sites in HeLa cells. RNA-interference-mediated depletion of ZRP-1 from HeLa cells revealed that ZRP-1 is essential not only for the formation of stress fibers and assembly of mature focal adhesions, but also for the actin reorganization at cell-cell contact sites and for correct cell-cell adhesion and, thus, for collective cell migration. Impairment of focal adhesions and stress fibers caused by ZRP-1 depletion has been associated with reduced tyrosine phosphorylation of FAK. However, maturation of focal adhesions could not be recovered by expression of active FAK. Interestingly, stress fibers in ZRP-1-depleted cells were ameliorated by exogenous expression of RhoA. We also found that total Rac1 activity is elevated in ZRP-1-depleted cells, resulting in abnormal burst of actin polymerization and dynamic membrane protrusions. Taken together, we conclude that that ZRP-1 plays a crucial role in coupling the cell-matrix/cell-cell-contact signals with Rho GTPase-mediated actin remodeling by localizing at cell-matrix and cell-cell contact sites.

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Publishing Authors By Initials

CY Bai,M Ohsugi,Y Abe,T Yamamoto,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: rhoa gtp-binding protein research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: rho gtp-binding proteins: rhoa gtp-binding protein research

PUBMED ID PMID:

MEDLINE DATE:

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 2828-37

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 24

MONTH: 07

YEAR: 2007

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 52457

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Keywords Mesh Terms:

KEYWORDS: rhoA GTP-Binding Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions. Information

Substance Name: rhoA GTP-Binding Protein

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions.

AFFILIATION: Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

ZRP-1 controls Rho GTPase-mediated actin reorganization by localizing at cell-matrix and cell-cell adhesions Related Publications

• CO2-enhanced sonographically guided radiofrequency ablation and transcatheter arterial chemoembolization for small hepatocellular carcinoma poorly defined on conventional sonography.
• Contested dominance modifies the anovulatory consequences of social subordination in female marmosets.
• Decreased fractal correlation in diurnal physical activity in chronic fatigue syndrome.
• Descriptive study of gallbladder, extrahepatic bile duct, and ampullary cancers in the United States, 1997-2002.
• Diastereo- and enantioselective synthesis of nitroso Diels-Alder-type bicycloketones using dienamine: mechanistic insight into sequential nitroso Aldol/Michael reaction and application for optically pure 1-amino-3,4-diol synthesis.
• Drosophila CTLA-2-like protein (D/CTLA-2) inhibits cysteine proteinase 1 (CP1), a cathepsin L-like enzyme.
• Dynamic changes in vesicular glutamate transporter 1 function and expression related to methamphetamine-induced glutamate release.
• Effects of bilateral jugular vein ligation on local cerebral blood flow.
• Effects of brain lesions on taste-potentiated odor aversion in rats.
• Effects of chronic unpredictable stress and methamphetamine on hippocampal glutamate function.
• Evaluation of osteogenic/chondrogenic cellular proliferation and differentiation in the xenogeneic periosteal graft.
• Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma.
• Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata.
• Imaging of Regional Differences of Muscle Oxygenation during Exercise Using Spatially Resolved NIRS.
• Interactions between methamphetamine and environmental stress: role of oxidative stress, glutamate and mitochondrial dysfunction.
• Intraoperative electro-oculographic Monitoring for Skull Base Surgery.
• Involvement of the Mesolimbic System in Palatability-induced Ingestion.
• Ketamine and N-acetylaspartylglutamate peptidase inhibitor exert analgesia in bone cancer pain.
• Kinetic mechanism of the fastest motor protein, Chara myosin.
• Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
• Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation.
• Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
• Negative regulation of BMP/Smad signaling by Tob in osteoblasts.
• Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor.
• Regulation of Wnt signalling by receptor-mediated endocytosis.
• Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression.
• The Role of Orexigenic Neuropeptides in the Ingestion of Sweet-tasting Substances in Rats.
• The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology.
• The use of polylactic acid/polyglycolic acid copolymer and gelatin sponge complex containing human recombinant bone morphogenetic protein-2 following condylectomy in rabbits.
• Trehalose Sensitivity of the Gustatory Receptor Neurons Expressing Wild-type, Mutant and Ectopic Gr5a in Drosophila.