Ziprasidone-associated depressive state in schizophrenic patients.

Ziprasidone-associated depressive state in schizophrenic patients. Research Abstract Details 

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Ziprasidone-associated depressive state in schizophrenic patients. Abstract Text:

Alexander Kaptsan,Tzvi Dwolatzky,Vladimir Lerner,Alexander Kaptsan,Tzvi Dwolatzky,Vladimir Lerner,

OBJECTIVES:: Although depression is a recognized side effect of many medications, the association of this condition with neuroleptics has received limited attention in the literature. Atypical antipsychotics may demonstrate a beneficial effect on affective symptoms. On the other hand, they may also cause depression both in those with and without a history of psychiatric illness. Although ziprasidone has been reported to have antidepressive properties, we are not aware of reports regarding ziprasidone-induced depression. METHODS:: We describe 3 cases of ziprasidone-associated depression in patients treated for schizophrenia who had no previous history of depressive illness. To the best of our knowledge, this is the first description of such an association. CONCLUSIONS:: This case series suggests that atypical antipsychotics may have a causal relationship in the development of depression in schizophrenic patients. This is noteworthy because these medications have been found in the past to have an antidepressant action. If neuroleptic-induced depression is mistaken for negative symptoms of schizophrenia, this condition may go untreated. Further data based on controlled studies are required.

Ziprasidone-associated depressive state in schizophrenic patients. Publishing Authors By Initials

A Kaptsan,T Dwolatzky,V Lerner,A Kaptsan,T Dwolatzky,V Lerner,

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Ziprasidone-associated depressive state in schizophrenic patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical neuropharmacology

VOLUME: 30

Page Numbers: 357-61

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ISSN: 0362-5664

DAY: 19

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7607910

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AFFILIATION: Division of Psychiatry, Ministry of Health Mental Health Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.

Country: United States

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MEDLINETA: Clin Neuropharmacol

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