Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo.

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Research Abstract Details 

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Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Abstract Text:

Huarong Zhou,Tao Zhang,Jamie S Harmon,Joseph Bryan,R Paul Robertson,

The intra-islet insulin hypothesis proposes that the decrement in beta-cell insulin secretion during hypoglycemia provides an activation signal for alpha-cells to release glucagon. A more recent hypothesis proposes that zinc atoms suppress glucagon secretion via their ability to open alpha-cell ATP-sensitive K(+) channels. Since insulin binds zinc, and zinc is co-secreted with insulin, we tested whether decreased zinc delivery to the alpha-cell activates glucagon secretion. In streptozotocin-induced diabetic Wistar rats, we observed that switching off intrapancreatic artery insulin infusions in vivo during hypoglycemia greatly improved glucagon secretion (area under the curve [AUC]: control group 240 +/- 261 and experimental group 4,346 +/- 1,259 pg x ml(-1) x 90 min(-1); n = 5, P < 0.02). Switching off pancreatic artery infusions of zinc chloride during hypoglycemia also improved the glucagon response (AUC: control group 817 +/- 107 and experimental group 3,445 +/- 573 pg x ml(-1) x 90 min(-1); n = 6, P < 0.01). However, switching off zinc-free insulin infusions had no effect. Studies of glucose uptake in muscle and liver cell lines verified that the zinc-free insulin was biologically active. We conclude that zinc atoms, not the insulin molecule itself, provide the switch-off signal from the beta-cell to the alpha-cell to initiate glucagon secretion during hypoglycemia.

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Publishing Authors By Initials

H Zhou,T Zhang,JS Harmon,J Bryan,RP Robertson,

For similar inorganic chemicals: elements: metals, heavy: zinc research abstracts see: inorganic chemicals: elements: metals, heavy: zinc research

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Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes

VOLUME: 56

Page Numbers: 1107-12

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 22

MONTH: 02

YEAR: 2007

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372763

Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Keywords Mesh Terms:

KEYWORDS: Zinc

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo. Information

Substance Name: Glucagon

Registry Number: 9007-92-5

Grant and Affiliation Information for Zinc, not insulin, regulates the rat alpha-cell response to hypoglycemia in vivo.

AFFILIATION: Pacific Northwest Research Institute, 720 Broadway, Seattle, WA 98122, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01-DK39994

ACRONYM: DK

MEDLINETA: Diabetes

REFSOURCE: Diabetes. 2007 Jun;56(6):1747

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