Zinc: mechanisms of host defense.

Zinc: mechanisms of host defense. Research Abstract Details 

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Zinc: mechanisms of host defense. Abstract Text:

Ananda S Prasad,

Zinc deficiency in humans decreases the activity of serum thymulin (a thymic hormone), which is required for maturation of T-helper cells. T-helper 1 (Th(1)) cytokines are decreased but T-helper 2 (Th(2)) cytokines are not affected by zinc deficiency in humans. This shift of Th(1) to Th(2) function results in cell-mediated immune dysfunction. Because IL-2 production (Th(1) cytokine) is decreased, this leads to decreased activities of natural-killer cell and T cytolytic cells, which are involved in killing viruses, bacteria, and tumor cells. In humans, zinc deficiency may decrease the generation of new CD4+ T cells from the thymus. In cell culture studies (HUT-78, a Th(0) human malignant lymphoblastoid cell line), as a result of zinc deficiency, nuclear factor-kappaB (NF-kappaB) activation, phosphorylation of IkappaB, and binding of NF-kappaB to DNA are decreased and this results in decreased Th(1) cytokine production. In another study, zinc supplementation to humans decreased the gene expression and production of pro-inflammatory cytokines and decreased oxidative stress markers. In HL-60 cells (a human pro-myelocytic leukemia cell line), zinc deficiency increased the levels of TNF-alpha, IL-1beta, and IL-8 cytokines and mRNA. In these cells, zinc induced A20, a zinc finger protein that inhibited NF-kappaB activation via tumor necrosis factor receptor associated factor pathway, and this decreased gene expression of pro-inflammatory cytokines and oxidative stress markers. We conclude that zinc has an important role in cell-mediated immune functions and also functions as antiinflammatory and antioxidant agent.

Zinc: mechanisms of host defense. Publishing Authors By Initials

AS Prasad,

For similar inorganic chemicals: elements: metals, heavy: zinc research abstracts see: inorganic chemicals: elements: metals, heavy: zinc research

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Zinc: mechanisms of host defense. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of nutrition

VOLUME: 137

Page Numbers: 1345-9

Journal Abbreviation:

ISSN: 0022-3166

DAY: 3

MONTH: May

YEAR: 2007

Zinc: mechanisms of host defense. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404243

Zinc: mechanisms of host defense. Keywords Mesh Terms:

KEYWORDS: Zinc

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Zinc: mechanisms of host defense. Information

Substance Name: Zinc

Registry Number: 7440-66-6

Grant and Affiliation Information for Zinc: mechanisms of host defense.

AFFILIATION: Department of Internal Medicine, Division of Hematology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. prasada@karmanos.org

Country: United States

AGENCY: United States PHS

GRANT: R01 A150698-04

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MEDLINETA: J Nutr

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