Zinc finger-based knockout punches for zebrafish genes.

Zinc finger-based knockout punches for zebrafish genes. Research Abstract Details 

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Zinc finger-based knockout punches for zebrafish genes. Abstract Text:

The ability to manipulate the genome is critical to develop and test hypotheses based on genetics. Knockdown strategies focused on RNAi and/or morpholinos are excellent genetic tools, but they come with substantial technical limitations. A new gene targeting approach employing synthetic zinc finger nuclease (ZFN) technology is a powerful and complementary approach to directly modify genetic loci for many diverse applications, notably enhancing Danio rerio (the zebrafish) as an experimental organism for understanding human disease. This ZFN-based technology to generate targeted knockouts in this aquatic animal opens the door to an array of new biological models of human disease and genetic testing.

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Zinc finger-based knockout punches for zebrafish genes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zebrafish

VOLUME: 5

Page Numbers: 121-3

Journal Abbreviation: Zebrafish

ISSN: 1557-8542

DAY: 16

MONTH: 06

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 101225070

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Grant and Affiliation Information for Zinc finger-based knockout punches for zebrafish genes.

AFFILIATION: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.

Country: United States

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MEDLINETA: Zebrafish

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