Zebrafish as a genomics research model.

Zebrafish as a genomics research model. Research Abstract Details 

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Zebrafish as a genomics research model. Abstract Text:

The zebrafish (Danio rerio) is a recent addition to the genomic scientists' repertoire of vertebrate animal model systems. Unlike simple invertebrates such as the fly or the nematode, this teleost maintains the biological and genomic complexity found in higher vertebrates. Furthermore, the zebrafish has many advantageous technical and genomic properties that open the door to experimental approaches not practical using more classical models. The zebrafish genome can be functionally accessed using both forward and reverse genetics based approaches. A notable recent addition to the zebrafish genomics toolbox is the development of morpholino-based antisense gene inhibition for sequence-based 'knockdown' screening. This method offers the opportunity to examine the role of significant subsets of the vertebrate genome for specific gene function in vivo. The zebrafish embryo can rapidly provide critical information for drug target discovery purposes when examined with an emphasis on clinically-relevant biological processes. Finally, the advent of chemical genetics in zebrafish suggests that, in addition to the identification and understanding of drug targets and their biology, this system will be a powerful tool in the direct development of novel pharmaceuticals in the near future.

Zebrafish as a genomics research model. Publishing Authors By Initials

For similar animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research abstracts see: animals: chordata: vertebrates: fishes: cypriniformes: cyprinidae: zebrafish research

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Zebrafish as a genomics research model. Journal Published:

PUBLICATION TYPE: Review

Journal: Current pharmaceutical biotechnology

VOLUME: 5

Page Numbers: 409-13

Journal Abbreviation: Curr Pharm Biotechnol

ISSN: 1389-2010

DAY: 12

MONTH: Oct

YEAR: 2004

Zebrafish as a genomics research model. Information

Number of References: 53

LANGUAGE: eng

NlmUniqueID: 100960530

Zebrafish as a genomics research model. Keywords Mesh Terms:

KEYWORDS: Zebrafish

MESH TERMS: physiology

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Grant and Affiliation Information for Zebrafish as a genomics research model.

AFFILIATION: Arnold and Mabel Beckman Center for Transposon Research, Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: GM63904

ACRONYM: GM

MEDLINETA: Curr Pharm Biotechnol

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