[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia]

[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia] Research Abstract Details 

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[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia] Abstract Text:

Yu-Jie Wu,Jian-Yong Li,Guang-Rong Zhu,Jun-Hong Song,Bin Xiao,Yu-Jie Wu,Jian-Yong Li,Guang-Rong Zhu,Jun-Hong Song,Bin Xiao,

To explore the ZAP-70 expression in chronic lymphocytic leukaemia (CLL) and its relationship with other prognostic factors, the expressions of ZAP-70 protein and CD38 in bone marrow or peripheral blood of 24 patients with B-CLL were determined by four-color flow cytometry. The results showed that ZAP-70 was positively expressed in 37.5% of all B-CLL patients, 20% (3/15) patients in Binet A stage, and 66.7% in Binet B + C. The expression of ZAP-70 had significant difference between Binet A and Binet B + C (P < 0.05). CD38 was expressed in 29.1% of B-CLL patients and 3 out of these cases were in stage A, 2 out of 3 cases in stage A co-expressed CD38 and ZAP-70. The expression of CD38 had no significant difference between Binet A and Binet B + C stage (P > 0.05). ZAP-70+ and CD38+ were both expressed in 83.3% of B-CLL patients (P < 0.05). It is concluded that ZAP-70 protein can be routinely measured by flow cytometry in the laboratory. High expression of ZAP-70 is correlated with other prognostic factors such as clinic stage, chromosome abnormalities and CD38 in B-CLL.

[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia] Publishing Authors By Initials

YJ Wu,JY Li,GR Zhu,JH Song,B Xiao,YJ Wu,JY Li,GR Zhu,JH Song,B Xiao,

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[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo shi yan xue ye xue za zhi / Zhongguo bing

VOLUME: 14

Page Numbers: 237-40

Journal Abbreviation: Zhongguo Shi Yan Xue Ye Xue Za

ISSN: 1009-2137

DAY: 26

MONTH: Apr

YEAR: 2006

[ZAP-70 expression in 24 patients with B cell chronic lymphocytic leukemia] Information

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LANGUAGE: chi

NlmUniqueID: 101084424

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AFFILIATION: Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province People Hospital, Nanjing 210029, China.

Country: China

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MEDLINETA: Zhongguo Shi Yan Xue Ye Xue Za

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