Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report.

Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Research Abstract Details 

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Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Abstract Text:

D P Puliyanda,D M Stablein,V R Dharnidharka,

Infections now exceed rejection as a cause of hospitalization in the first 2 years post-renal transplantation. We analyzed data from the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS) to determine risks for hospitalization for infection (HI), either bacterial (HBI) or viral (HVI). 3106 children transplanted between 1996 and 2002 with 2-year follow-up were analyzed. Univariate and multivariate logistic regression analyses identified factors for cause-specific hospitalization. Results: 23.4% experienced HBI, 23.9% HVI; 8.9% were hospitalized for both. Children 0-1 years age at transplant had higher rates of HI (64.2%), HBI (40.3%) and HVI (43.3%) compared to >12 years (31%, 17.5% and 18.9%, p < 0.0001). In comparison to no induction, patients receiving monoclonal or polyclonal antibody were more likely to have HI (>42% vs. 34.0%), HBI (>24% vs. 21%) or HVI (>29% vs. 21%, all p < 0.003) but had equivalent graft survival (p = NS). Higher rates of HI, HBI and HVI were also seen with prophylactic antimicrobial use and with >5 transfusions pretransplant. Since antibody induction in recent era was not associated with better graft or patient survival but was associated with more HI and HVI, the need for routine antibody induction in children needs to be reassessed.

Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Publishing Authors By Initials

DP Puliyanda,DM Stablein,VR Dharnidharka,

For similar virus diseases research abstracts see: virus diseases research

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Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 662-6

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 22

MONTH: 01

YEAR: 2007

Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Information

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LANGUAGE: eng

NlmUniqueID: 100968638

Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report. Information

Substance Name: Antibodies

Registry Number: 0

Grant and Affiliation Information for Younger age and antibody induction increase the risk for infection in pediatric renal transplantation: a NAPRTCS report.

AFFILIATION: Pediatric Nephrology, Cedars Sinai Medical Center, Los Angeles, CA, USA.

Country: Denmark

AGENCY: United States NIDDK

GRANT: 1R21 DK 069525

ACRONYM: DK

MEDLINETA: Am J Transplant

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