Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer.

Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Research Abstract Details 

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Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Abstract Text:

Katherine E Posther,Linda M McCall,David H Harpole,Carolyn E Reed,Joe B Putnam,Valerie W Rusch,Barry A Siegel,

The American College of Surgeons Oncology Group recently completed a trial evaluating the role of PET with 18F-FDG in patients with documented or suspected non-small cell lung cancer. Subjects underwent standard imaging to exclude metastatic disease before PET. Here, we report the yield of brain PET in evaluating, for potential intracranial metastases, patients who have undergone previous brain CT or MRI with negative findings. METHODS: A total of 287 evaluable patients who had been registered from 22 institutions underwent whole-body 18F-FDG PET, including dedicated PET of the brain, after routine staging procedures had found no suggestion of metastatic disease. Patients were followed postoperatively for disease-free and overall survival, with a minimum follow-up of 6 mo. Patients with specific brain abnormalities identified by PET were further examined, and the findings were evaluated along with the results of CT and MRI, clinical management, and follow-up. RESULTS: In 4 patients, PET found focal 18F-FDG uptake in the brain suggestive of metastatic disease; however, metastatic disease was excluded clinically in all 4 by negative findings on further brain imaging. All 4 patients remained alive at follow-up (mean duration, 10.5 mo; range, 6-16 mo). CONCLUSION: In patients with suspected or proven non-small cell lung cancer considered resectable by standard imaging, including routine preoperative contrast-enhanced CT or MRI of the brain, PET of the brain provides no additional information regarding metastatic disease.

Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Publishing Authors By Initials

KE Posther,LM McCall,DH Harpole,CE Reed,JB Putnam,VW Rusch,BA Siegel,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: whole body imaging research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: whole body imaging research

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Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of nuclear medicine : official publication

VOLUME: 47

Page Numbers: 1607-11

Journal Abbreviation: J. Nucl. Med.

ISSN: 0161-5505

DAY: 3

MONTH: Oct

YEAR: 2006

Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 217410

Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Keywords Mesh Terms:

KEYWORDS: Whole Body Imaging

MESH TERMS: diagnostic use

Chemical & Substance for Abstract: Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer. Information

Substance Name: Fluorodeoxyglucose F18

Registry Number: 63503-12-8

Grant and Affiliation Information for Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer.

AFFILIATION: Department of Surgery, Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, North Carolina, USA.

Country: United States

AGENCY: United States NCI

GRANT: U10 CA76001-09

ACRONYM: CA

MEDLINETA: J Nucl Med

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