Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Research Abstract Details 

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Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Abstract Text:

Emily C Colgate,Cristobal L Miranda,Jan F Stevens,Tammy M Bray,Emily Ho,

There is increasing evidence that certain natural compounds found in plants may be useful as cancer chemopreventive or chemotherapeutic agents. Limited in vitro studies indicate that several prenylated flavonoids present in the hop plant (Humulus lupulus) possess anticarcinogenic properties. The purpose of this study was to investigate the anti-tumorigenic effects of xanthohumol (XN), the major prenylflavonoid in hops, on prostate cancer and benign prostate hyperplasia. BPH-1 and PC3 cell lines were used in our study to represent both non-tumorigenic hyperplasia and malignant prostate cancer. In both BPH-1 and PC3 cells, XN and its oxidation product, XAL, decreased cell viability in a dose dependent manner (2.5-20 microM) as determined by MTT assay and caused an increase in the formation of early and late apoptotic cells as determined by Annexin V staining and multicaspase assays. XN and its oxygenated derivative also induced cell cycle changes in both cells lines, seen in an elevated sub G1 peak at 48h treatment. Western blot analysis was performed to confirm the activation of proapoptotic proteins, Bax and p53. XN and its derivative caused decreased activation of NFkappaB. This work suggests that XN and its oxidation product, XAL, may be potentially useful as a chemopreventive agent during prostate hyperplasia and prostate carcinogenesis, acting via induction of apoptosis and down-regulation of NFkappaB activation in BPH-1 cells.

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Publishing Authors By Initials

EC Colgate,CL Miranda,JF Stevens,TM Bray,E Ho,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, male: prostatic neoplasms research

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Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer letters

VOLUME: 246

Page Numbers: 201-9

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 24

MONTH: 03

YEAR: 2006

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600053

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Keywords Mesh Terms:

KEYWORDS: Prostatic Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells. Information

Substance Name: xanthohumol

Registry Number: 6754-58-1

Grant and Affiliation Information for Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.

AFFILIATION: Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA.

Country: Ireland

AGENCY: United States NIEHS

GRANT: P30 ES00210

ACRONYM: ES

MEDLINETA: Cancer Lett

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