X-tra! X-tra! News from the mouse X chromosome.

X-tra! X-tra! News from the mouse X chromosome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

X-tra! X-tra! News from the mouse X chromosome. Abstract Text:

Joanne L Thorvaldsen,Raluca I Verona,Marisa S Bartolomei,

X chromosome inactivation (XCI) is the phenomenon through which one of the two X chromosomes in female mammals is silenced to achieve dosage compensation with males. XCI is a highly complex, tightly controlled and developmentally regulated process. The mouse undergoes two forms of XCI: imprinted, which occurs in all cells of the preimplantation embryo and in the extraembryonic lineage, and random, which occurs in somatic cells after implantation. This review presents results and hypotheses that have recently been proposed concerning important aspects of both imprinted and random XCI in mice. We focus on how imprinted XCI occurs during preimplantation development, including a brief discussion of the debate as to when silencing initiates. We also discuss regulation of random XCI, focusing on the requirement for Tsix antisense transcription through the Xist locus, on the regulation of Xist chromatin structure by Tsix and on the effect of Tsix regulatory elements on choice and counting. Finally, we review exciting new data revealing that X chromosomes co-localize during random XCI. To conclude, we highlight other aspects of X-linked gene regulation that make it a suitable model for epigenetics at work.

X-tra! X-tra! News from the mouse X chromosome. Publishing Authors By Initials

JL Thorvaldsen,RI Verona,MS Bartolomei,

For similar genetic processes: gene expression regulation: epigenesis, genetic: dosage compensation, genetic: x chromosome inactivation research abstracts see: genetic processes: gene expression regulation: epigenesis, genetic: dosage compensation, genetic: x chromosome inactivation research

PUBMED ID PMID:

MEDLINE DATE:

X-tra! X-tra! News from the mouse X chromosome. Journal Published:

PUBLICATION TYPE: Review

Journal: Developmental biology

VOLUME: 298

Page Numbers: 344-53

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 15

MONTH: 07

YEAR: 2006

X-tra! X-tra! News from the mouse X chromosome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

X-tra! X-tra! News from the mouse X chromosome. Keywords Mesh Terms:

KEYWORDS: X Chromosome Inactivation

MESH TERMS: physiology

Chemical & Substance for Abstract: X-tra! X-tra! News from the mouse X chromosome. Information

Substance Name: X (inactive)-specific transcript (XIST)

Registry Number: 0

Grant and Affiliation Information for X-tra! X-tra! News from the mouse X chromosome.

AFFILIATION: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM74768

ACRONYM: GM

MEDLINETA: Dev Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

X-tra! X-tra! News from the mouse X chromosome Related Publications

• A bond-bond description of the intermolecular interaction energy: the case of weakly bound N(2)-H(2) and N(2)-N(2) complexes.
• Chapter 7 Regulation of Imprinting in Clusters: Noncoding RNAs Versus Insulators.
• Different crystal morphologies arising from different preparation methods of a same polymorphic form may result in different properties of the final materials: The case of diclofenac sodium trihydrate.
• Enhanced EEG functional connectivity in mesial temporal lobe epilepsy.
• Functional interactions in brain networks underlying epileptic seizures in bilateral diffuse periventricular heterotopia.
• Identification of candidate maternal-effect genes through comparison of multiple microarray data sets.
• Maintenance of paternal methylation and repression of the imprinted H19 gene requires MBD3.
• Manipulations of mouse embryos prior to implantation result in aberrant expression of imprinted genes on day 9.5 of development.
• Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development.
• Modeling EEG signals and interpreting measures of relationship during temporal-lobe seizures: an approach to the study of epileptogenic networks.
• Ribonuclease protection.
• The transcriptional status but not the imprinting control region determines allele-specific histone modifications at the imprinted h19 locus.
• Three-dimensional conformation at the H19/Igf2 locus supports a model of enhancer tracking.
• X-tra! X-tra! News from the mouse X chromosome.
• [Histochemical research on endometrial glycogen in uterine fibromatosis.]