X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension.

X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Research Abstract Details 

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X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Abstract Text:

Maja Zivkovi?,Tamara Djuri?,Olja Stanci?,Dragan Alavanti?,Aleksandra Stankovi?,Maja Zivkovi?,Tamara Djuri?,Olja Stanci?,Dragan Alavanti?,Aleksandra Stankovi?,Maja Zivkovi?,Tamara Djuri?,Olja Stanci?,Dragan Alavanti?,Aleksandra Stankovi?,

BACKGROUND: The role of AT2R in regulation of blood pressure (BP) was mainly investigated in animal models. It is proposed to be a negative regulator of BP. X-linked AT2R -1332 A/G polymorphism has been denoted as functional. This polymorphism was associated with certain cardiovascular phenotypes in hypertensive patients, but it was poorly investigated in essential hypertension. The aim of our study was to evaluate possible association of -1332 A/G gene polymorphism with essential hypertension in males from Serbian population. METHODS: The study group included 304 men of Caucasian origin, 190 normotensive (NT) and 114 hypertensive (HT), free of cardiovascular disorders. Genotyping was done by PCR RFLP method. RESULTS: G/- genotype was in association with HT (OR 1.6, CI=1.0-2.6, p=0.04). Stratification by age (<40 years, mean 31.65+/-5.29 and >40 years, mean 51.36+/-8.32) pronounced significance only in older males (OR 2.4, CI=1.2-5.0, p=0.02). After adjustment for confounding factors the OR for hypertension remained unchanged and significant (adjusted OR 2.3, CI=1.0-5.4, p=0.04). Conclusion: Hemizygosity for the G allele was found to be susceptibility factor for hypertension in males. Still, clarifying the role of AT2R in development of human hypertension requires further replication studies in larger and different populations.

X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Publishing Authors By Initials

M Zivkovi?,T Djuri?,O Stanci?,D Alavanti?,A Stankovi?,M Zivkovi?,T Djuri?,O Stanci?,D Alavanti?,A Stankovi?,M Zivkovi?,T Djuri?,O Stanci?,D Alavanti?,A Stankovi?,

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X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinica chimica acta; international journal of cli

VOLUME: 386

Page Numbers: 110-3

Journal Abbreviation: Clin. Chim. Acta

ISSN: 0009-8981

DAY: 19

MONTH: 07

YEAR: 2007

X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension. Information

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LANGUAGE: eng

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Grant and Affiliation Information for X-linked angiotensin II type 2 receptor gene polymorphism -1332A/G in male patients with essential hypertension.

AFFILIATION: VINCA Institute of Nuclear Sciences, Laboratory for Radiobiology and Molecular Genetics, Belgrade, Serbia.

Country: Netherlands

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MEDLINETA: Clin Chim Acta

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