[X chromosome inactivation--a biological phenomenon of clinical significance for women]

[X chromosome inactivation--a biological phenomenon of clinical significance for women] Research Abstract Details 

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[X chromosome inactivation--a biological phenomenon of clinical significance for women] Abstract Text:

In female mammals one of the two X chromosomes is inactivated in early embryonic life. Females are therefore mosaics for two cell types, cells with the maternal X as the active X chromosome, and cells with the paternal X as the active X chromosome. The process of X inactivation is random and permanent for each cell. A skewed X chromosome inactivation pattern may be defined as a pattern where the ratio between the two cell types is 80:20 or more. Skewed X inactivation may have several causes. Since X inactivation is a stochastic event, a skewed pattern may be the result of a chance occurrence. It may also be the result of genetic factors, or be the result of a selection leading to a growth advantage for one of the two cell types. A selection mechanism may be the reason for the increase in the frequency of skewed X inactivation found in normal elderly females. An important consequence of skewed X inactivation is the manifestation of X-linked disease in female carriers.

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[X chromosome inactivation--a biological phenomenon of clinical significance for women] Journal Published:

PUBLICATION TYPE: Review

Journal: Tidsskrift for den Norske lægeforening : tidsskrif

VOLUME: 119

Page Numbers: 972-5

Journal Abbreviation: Tidsskr. Nor. Laegeforen.

ISSN: 0029-2001

DAY: 10

MONTH: Mar

YEAR: 1999

[X chromosome inactivation--a biological phenomenon of clinical significance for women] Information

Number of References: 21

LANGUAGE: nor

NlmUniqueID: 413423

[X chromosome inactivation--a biological phenomenon of clinical significance for women] Keywords Mesh Terms:

KEYWORDS: X Chromosome

MESH TERMS: genetics

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Grant and Affiliation Information for [X chromosome inactivation--a biological phenomenon of clinical significance for women]

AFFILIATION: Avdeling for medisinsk genetikk Ullevål sykehus, Oslo.

Country: NORWAY

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MEDLINETA: Tidsskr Nor Laegeforen

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