X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function.

X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Research Abstract Details 

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X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Abstract Text:

K Brockmeier,L Schmitz,A von Moers,H Koch,M Vogel,G Bein,

In order to screen for cardiac abnormalities, we prospectively studied 15 patients (age 8-25 years, mean 15.5 years) with Duchenne's (DMD) (n = 9) and Becker's (BMD) (n = 6) muscular dystrophy using the echocardiogram. Data were compared to a control group of 92 healthy individuals (age 7.9-25 years, mean 14.3 years). Left ventricular filling in diastole showed a different pattern when comparing echocardiographic Doppler results in patients and controls: Patients had lower peak velocity of early left ventricular diastolic filling (E-vmax)(P < 0.0001) and smaller time velocity integral of the E-wave (E-tvi)(P < 0.0001). In contrast, the atrial component (A-vmax, A-tvi) of diastolic filling in DMD/ BMD showed no significant difference to controls. The mean area of the mitral valve orifice was significantly larger in patients (P < 0.0001) without presence of mitral regurgitation. Systolic left ventricular function was significantly impaired in the DMD/BMD group; we found lower heart rate corrected fiber shortening velocity VCFc (P < 0.001) and higher peak systolic wall stress (P < 0.001) in DMD/BMD. In 8 of 15 patients, peak systolic wall stress was above 95th percentile of controls. In 6 of 15 patients, VCFc was lower than the 5th percentile of controls. Systolic and diastolic myocardial impairment was found even in young patients and at low stages of disability--equally among patients with DMD or BMD. Diastolic left ventricular impairment predominantly affected the early diastolic filling, but atrial compensation was poor. Peak systolic wall stress measurements were particularly useful in patients with CMP, reflecting the left ventricular afterload.

X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Publishing Authors By Initials

K Brockmeier,L Schmitz,A von Moers,H Koch,M Vogel,G Bein,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular function, left research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular function, left research

PUBMED ID PMID:

MEDLINE DATE: 1998 Mar-Apr

X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric cardiology

VOLUME: 19

Page Numbers: 139-44

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 20

MONTH: 02

YEAR: 2008

X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function. Keywords Mesh Terms:

KEYWORDS: Ventricular Function, Left

MESH TERMS: physiopathology

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Grant and Affiliation Information for X-chromosomal (p21) muscular dystrophy and left ventricular diastolic and systolic function.

AFFILIATION: Department of Pediatric Cardiology, Children's Hospital, Virchow Medical Center, Humboldt University, Berlin, Germany.

Country: UNITED STATES

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MEDLINETA: Pediatr Cardiol

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