X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas.

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Abstract Text:

Yi-Ran Cai,Xiao-Li Diao,Shu-Fang Wang,Wei Zhang,Hong-Tu Zhang,Qin Su,Yi-Ran Cai,Xiao-Li Diao,Shu-Fang Wang,Wei Zhang,Hong-Tu Zhang,Qin Su,Yi-Ran Cai,Xiao-Li Diao,Shu-Fang Wang,Wei Zhang,Hong-Tu Zhang,Qin Su,

Uterine leiomyomas were shown to be clonal lesions, but the relationship among different tumor nodules in multiple uterine leiomyomas remains unresolved. In this study, X-chromosomal inactivation patterns of these tumor nodules were shown by allelic polymorphism analysis through polymerase-chain reaction at the phosphoglycerate kinase and androgen receptor loci following pretreatment with the methylation-sensitive restriction enzyme HpaII or HhaI. A total number of 113 cases of uterine leiomyomas were examined. Monoclonality was demonstrated in all of the 315 nodules from 76 informative cases. The inter-nodular relationship was evaluated in 55 multiple cases with 294 tumor nodules. Different inactivation patterns were observed in 20 cases, demonstrating a multicentric origin, while an identical inactivated allele was found in all or most of the nodules in the rest of the cases, indicating a common clonal origin. The occurrence of the unicentric cases appeared to be associated with an elevated mitotic activity. Seven nodules from a multinodular case with a morphology indicative of mitotically active leiomyoma were shown to carry the identical inactivated allele, which demonstrates their unicellular origin and malignant nature. In addition, the same androgen receptor gene alteration was identified in two discrete leiomyoma nodules from a uterus. These results approve the monoclonality of uterine leiomyomas and demonstrate the presence of unicentric multiple leiomyomas.

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Publishing Authors By Initials

YR Cai,XL Diao,SF Wang,W Zhang,HT Zhang,Q Su,YR Cai,XL Diao,SF Wang,W Zhang,HT Zhang,Q Su,YR Cai,XL Diao,SF Wang,W Zhang,HT Zhang,Q Su,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oncology

VOLUME: 31

Page Numbers: 1379-89

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 5

MONTH: Dec

YEAR: 2007

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9306042

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas.

AFFILIATION: Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China.

Country: Greece

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

X-chromosomal inactivation analysis of uterine leiomyomas reveals a common clonal origin of different tumor nodules in some multiple leiomyomas Related Publications

• Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes.
• Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells.
• Hepatitis C in pregnancy.
• In Vivo and in Vitro Evaluation of Essential Oils from Ligusticum chuanxiong HORT on the Transdermal Delivery of Flurbiprofen in Rabbits.
• Study on relationship between carbon disulfide exposure and symptoms and signs of nervous system in workers.
• [A study on training method for increasing adaptability to blood redistribution in human]
• [Age-related and menopause-related changes of urinary excretion of C- and N-terminal cross-linked telopeptides of type I collagen and the relationships thereof with menopause-related bone loss]
• [Angiotensin II contents in plasma, and cardiac and renal tissues of sinoaortic denervated rats]
• [Characteristics and therapeutic strategies of nosocomial pneumonia in postoperative patients with acute hypertensive intracerebral hemorrhage]
• [Effect of different methods for postoperative pain management on catecholamine response to abdominal surgery]
• [Effect of early exposure to allergen on rat asthmatic model]
• [Effect of temperature of fluid infusion on diamine oxidase, MB isoenzyme of creatine kinase, creatine-kinase and lactate dehydrogenase in hemorrhagic shock rabbits.]
• [Genetic polymorphism of 6 short tandem repeat loci in Mongolian population of China]
• [Identification of a novel B variant allele in a Chinese Han individual with B subgroup]
• [Past, present and future development of the project of manned space medico-engineering in China]
• [Progress in research on forest tree genomics]
• [Quick determination of lubricating oil additive by infrared spectrum method]
• [Research on the nonlinear model of near infrared spectroscopy and the total sugar of tobacco samples]
• [Separation of soybean agglutinin by hydrophobic-interaction chromatography]
• [Single nucleotide polymorphisms of genes associated with high density lipoprotein metabolism in Chinese population]
• [Smoking and subjective life qualities in middle school students]
• [Soft tissue treatment and esthetic effect in dental implantation surgery]
• [Studies on the chemical constituents of the alga Sargassum carpophyllum J. Agardh]
• [Study of genetic polymorphism of 6 short tandem repeat loci in Nongqu Mongolian of inner Mongolia Autonomous Region in China]
• [Study on quality of crude Ramulas Cinnamomi in different reserve period and their prepared products]
• [Study on the steroid constituents of soft coral Lobophytum microspiculatum]
• [The improvement of sample preparation for infrared spectroscopy analysis]
• [Therapeutic efficiency of nitric oxide synthase inhibitor on traumatic shock in rats]
• [Variant genotyping of CCR2-64I, SDF1-3' A and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors]
• [Ye shes dpal'byor and Gan lu si bu (The four Tantras of nectar)]