Worming out the biology of Runx.

Worming out the biology of Runx. Research Abstract Details 

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Worming out the biology of Runx. Abstract Text:

Rachael Nimmo,Alison Woollard,

Runx family transcription factors have risen to prominence over the last few years because of the increasing evidence implicating them as key regulators of the choice between cell proliferation and differentiation during development and carcinogenesis. Runx factors have been found to be involved in diverse developmental processes, ranging from hematopoiesis to neurogenesis, and are increasingly being linked with various human cancers. In this review, we examine the case for Runx factors as key regulators of cell proliferation in various developmental situations, a role that predisposes Runx mutations as causative agents in oncogenesis. We discuss the evidence that Runx factors regulate, and are regulated by, core components of the cell cycle machinery, and focus our attention on the solo Runx gene, rnt-1, in Caenorhabditis elegans, an organism that we feel has much to offer the Runx field.

Worming out the biology of Runx. Publishing Authors By Initials

R Nimmo,A Woollard,

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Worming out the biology of Runx. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 313

Page Numbers: 492-500

Journal Abbreviation: Dev. Biol.

ISSN: 1095-564X

DAY: 17

MONTH: 11

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372762

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AFFILIATION: Genetics Unit, Biochemistry Department, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

Country: United States

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MEDLINETA: Dev Biol

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