Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients.

Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Research Abstract Details 

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Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Abstract Text:

Takashi Nakashima,Dage Liu,Jun Nakano,Shinya Ishikawa,Hiroyasu Yokomise,Masaki Ueno,Kyuichi Kadota,Cheng-Long Huang,Takashi Nakashima,Dage Liu,Jun Nakano,Shinya Ishikawa,Hiroyasu Yokomise,Masaki Ueno,Kyuichi Kadota,Cheng-Long Huang,Takashi Nakashima,Dage Liu,Jun Nakano,Shinya Ishikawa,Hiroyasu Yokomise,Masaki Ueno,Kyuichi Kadota,Cheng-Long Huang,

The Wnt family genes encode multifunctional signaling glycoproteins that are involved in the regulation of a wide variety of normal and pathological processes including tumorigenesis. In order to clarify the clinical significance of the intratumoral Wnt1 expression in non-small cell lung cancer (NSCLC), we performed an immunohistochemical study on the Wnt1 expression in NSCLCs in relation to the tumor proliferation. The intratumoral Wnt1 protein expression appeared in a cytoplasmic staining pattern. Of the 151 NSCLCs studied, 61 carcinomas (40.4%) were Wnt1-positive. Regarding the tumor biology of the intratumoral Wnt1 expression, the Ki-67 proliferation index was significantly higher in Wnt1-positive than in Wnt1-negative tumors (P=0.0062). Furthermore, regarding the expression of c-Myc, one of the proliferation-regulating Wnt targets, the percentage of c-Myc-positive tumor cells was significantly higher in Wnt1-positive than in Wnt1-negative tumors (P=0.0019). The Ki-67 proliferation index was significantly higher in c-Myc-positive than in c-Myc-negative tumors (P=0.0239). The overall survival was significantly lower in patients with Wnt1-positive NSCLCs than in patients with Wnt1-negative NSCLCs (P=0.0003). A Cox regression analysis demonstrated that the Wnt1 status was a significant prognostic factor for NSCLC patients (hazard ratio 1.983; P=0.0061). Our results revealed that the Wnt1 overexpression affects the tumor proliferation in NSCLCs, partly via the upregulation of c-Myc.

Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Publishing Authors By Initials

T Nakashima,D Liu,J Nakano,S Ishikawa,H Yokomise,M Ueno,K Kadota,CL Huang,T Nakashima,D Liu,J Nakano,S Ishikawa,H Yokomise,M Ueno,K Kadota,CL Huang,T Nakashima,D Liu,J Nakano,S Ishikawa,H Yokomise,M Ueno,K Kadota,CL Huang,

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Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncology reports

VOLUME: 19

Page Numbers: 203-9

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 21

MONTH: Jan

YEAR: 2008

Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients.

AFFILIATION: Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan.

Country: Greece

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MEDLINETA: Oncol Rep

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