Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures.

Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Research Abstract Details 

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Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Abstract Text:

Marni A Slavik,B Lynn Allen-Hoffmann,Bob Y Liu,Caroline M Alexander,

BACKGROUND: Interfollicular skin develops normally only when the activity of the progenitor cells in the basal layer is counterbalanced by the exit of cells into the suprabasal layers, where they differentiate and cornify to establish barrier function. Distinct stem and progenitor compartments have been demonstrated in hair follicles and sebaceous glands, but there are few data to describe the control of interfollicular progenitor cell activity. Wnt signaling has been shown to be an important growth-inducer of stem cell compartments in skin and many other tissues. RESULTS: Here, we test the effect of ectopic Wnt1 expression on the behavior of interfollicular progenitor cells in an organotypic culture model, and find that Wnt1 signaling inhibits their growth and promotes terminal differentiation. CONCLUSION: These results are consistent with the phenotypes reported for transgenic mice engineered to have gain or loss of function of Wnt signaling in skin, which would recommend our culture model as an accurate one for molecular analysis. Since it is known that canonical ligands are expressed in skin, it is likely that this pathway normally regulates the balance of growth and differentiation, and suggests it could be important to pathogenesis.

Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Publishing Authors By Initials

MA Slavik,BL Allen-Hoffmann,BY Liu,CM Alexander,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins: wnt1 protein research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins: wnt1 protein research

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Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: BMC developmental biology

VOLUME: 7

Page Numbers: 9

Journal Abbreviation: BMC Dev. Biol.

ISSN: 1471-213X

DAY: 17

MONTH: 02

YEAR: 2007

Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100966973

Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Keywords Mesh Terms:

KEYWORDS: Wnt1 Protein

MESH TERMS: physiology

Chemical & Substance for Abstract: Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures. Information

Substance Name: Wnt1 Protein

Registry Number: 0

Grant and Affiliation Information for Wnt signaling induces differentiation of progenitor cells in organotypic keratinocyte cultures.

AFFILIATION: McArdle Lab for Cancer Research, University of Wisconsin Medical School-Madison, Madison, Wisconsin, USA. marnislavik@yahoo.com <marnislavik@yahoo.com>

Country: England

AGENCY: United States NHLBI

GRANT: R01-HL074284

ACRONYM: HL

MEDLINETA: BMC Dev Biol

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