Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation.

Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Research Abstract Details 

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Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Abstract Text:

Anenisia C Andrade,Ola Nilsson,Kevin M Barnes,Jeffrey Baron,Anenisia C Andrade,Ola Nilsson,Kevin M Barnes,Jeffrey Baron,

Longitudinal growth of long bones occurs at the growth plate by endochondral ossification. In the embryonic mouse, this process is regulated by Wnt signaling. Little is known about which members of the Wnt family of secreted signaling proteins might be involved in the regulation of the postnatal growth plate. We used microdissection and real-time PCR to study mRNA expression of Wnt genes in the mouse growth plate. Of the 19 known members of the Wnt family, only six were expressed in postnatal growth plate. Of these, Wnts -2b, -4, and -10b signal through the canonical beta-catenin pathway and Wnts -5a, -5b, and -11 signal through the noncanonical calcium pathway. The spatial expression for these six Wnts was remarkably similar, showing low mRNA expression in the resting zone, increasing expression as the chondrocytes differentiated into the proliferative and prehypertrophic state and then (except Wnt-2b) decreasing expression as the chondrocytes underwent hypertrophic differentiation. This overall pattern is broadly consistent with previous studies of embryonic mouse growth cartilage suggesting that Wnt signaling modulates chondrocyte proliferation and hypertrophic differentiation. We also found that mRNA expression of these Wnt genes persisted at similar levels at 4 weeks, when longitudinal bone growth is waning. In conclusion, we have identified for the first time the specific Wnt genes that are expressed in the postnatal mammalian growth plate. The six identified Wnt genes showed a similar pattern of expression during chondrocyte differentiation, suggesting overlapping or interacting roles in postnatal endochondral bone formation.

Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Publishing Authors By Initials

AC Andrade,O Nilsson,KM Barnes,J Baron,AC Andrade,O Nilsson,KM Barnes,J Baron,

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Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bone

VOLUME: 40

Page Numbers: 1361-9

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ISSN: 8756-3282

DAY: 20

MONTH: 01

YEAR: 2007

Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Information

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LANGUAGE: eng

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AFFILIATION: Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. anenisia@gmail.com

Country: United States

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MEDLINETA: Bone

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