Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord.

Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Research Abstract Details 

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Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Abstract Text:

Zong-Sheng Yin,Hui Zhang,Wei Wang,Xing-Yi Hua,Yong Hu,Sheng-Quan Zhang,Guang-Wu Li,Zong-Sheng Yin,Hui Zhang,Wei Wang,Xing-Yi Hua,Yong Hu,Sheng-Quan Zhang,Guang-Wu Li,

BACKGROUND: Wnt proteins as growth factor have multiple functions in neural development, and especially serve key roles in differentiation and development. Wnt-3a is an intercellular signaling molecule that is involved in a variety of morphogenetic events. The purpose of this study was to investigate the effects of Wnt-3a signal protein on proliferation and differentiation of neural stem cells derived from adult mouse spinal cord. METHODS: Adult mouse neural stem cells were cultured with serum free incubation. The recombined plasmid pSecTag2/Hygro B-Wnt3a for eukaryotic expression transfected adult neural stem cell, then the expression protein was detected by Western blot. The differentiation of adult neural stem cells was identified by the immunocytochemical technique. RESULTS: The inducing differentiated rates of neurons were improved greatly by Wnt-3a protein compared with control (p<0.05). CONCLUSION: Wnt-3a has obvious influence on the neuronal differentiation of adult neural stem cell.

Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Publishing Authors By Initials

ZS Yin,H Zhang,W Wang,XY Hua,Y Hu,SQ Zhang,GW Li,ZS Yin,H Zhang,W Wang,XY Hua,Y Hu,SQ Zhang,GW Li,

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Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurological research

VOLUME: 29

Page Numbers: 847-54

Journal Abbreviation: Neurol. Res.

ISSN: 0161-6412

DAY: 14

MONTH: Dec

YEAR: 2007

Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Wnt-3a protein promote neuronal differentiation of neural stem cells derived from adult mouse spinal cord.

AFFILIATION: Department of Orthopaedics, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China.

Country: England

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MEDLINETA: Neurol Res

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