Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Abstract Text:

Using a mouse predisposed to neoplasia by a germ line mutation in Apc (Apc(Min)), we tested whether induced hyperplasia is sufficient to increase intestinal tumor multiplicity or size in the intestine. We found that hyperplasia in the jejunum correlated with a significant increase in tumor multiplicity. However, tumor multiplicity was unchanged in the hyperplastic colon. This result indicates that even an intestine predisposed to neoplasia can, in certain regions including the colon, accommodate net increased cell growth without developing more neoplasms. Where hyperplasia correlated with increased tumor multiplicity, it did not increase the size or net growth of established tumors. This result suggests that the event linking hyperplasia and neoplasia in the jejunum is tumor establishment. Two novel observations arose in our study: the multiple intestinal neoplasia (Min) mutation partially suppressed both mitosis and transforming growth factor alpha-induced hyperplasia throughout the intestine; and zinc treatment alone increased tumor multiplicity in the duodenum of Min mice.

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Carcinogenesis

VOLUME: 29

Page Numbers: 1825-30

Journal Abbreviation: Carcinogenesis

ISSN: 1460-2180

DAY: 28

MONTH: 02

YEAR: 2008

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.

AFFILIATION: McArdle Laboratory for Cancer Research, Department of Oncology.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Carcinogenesis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis Related Publications

• A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer.
• A web-based approach to managing stress and mood disorders in the workforce.
• Atm is a negative regulator of intestinal neoplasia.
• Cellular expression patterns of genes upregulated in murine and human colonic neoplasms.
• Complete fractures of the femur in Paget's disease of bone.
• Emergence of class 1 integron-associated GES-5 and GES-5-like extended-spectrum beta-lactamases in clinical isolates of Pseudomonas aeruginosa in South Africa.
• Endocrine function in male and female homosexuals.
• Gene expression of a green fluorescent protein homolog as a host-specific biomarker of heat stress within a reef-building coral.
• Identification of Mom7, a novel modifier of Apc(Min/+) on mouse chromosome 18.
• Local and global regulators linking anaerobiosis to cupA fimbrial gene expression in Pseudomonas aeruginosa.
• Monitoring indoor CO2.
• Niche partitioning of closely related symbiotic dinoflagellates.
• Nifty transport device doubles durability of donor organs.
• Oestrogens in oophorectomized women.
• Pregnancy after liver transplantation.
• President's page: responding to the drum beat for health care reform.
• Progressive scoliosis as the first presenting sign of syringomyelia. Report of a case.
• Role of molecular charge and hydrophilicity in regulating the kinetics of crystal growth.
• The pleiotropic phenotype of apc mutations in the mouse: allele specificity and effects of the genetic background.
• Toaster oven helps researchers toy with microfluidics.
• Transcription terminators in lambda appendix Deletion of control sites in the pL operon of phage lambda.
• Treatment of acute myocardial infarction with intracoronary infusion of streptokinase.
• Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis.
• Widespread hyperplasia induced by transgenic TGF{alpha} in ApcMin mice is associated with only regional effects on tumorigenesis.