Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice.

Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Research Abstract Details 

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Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Abstract Text:

Vivian R Whitaker,Lin Cui,Scott Miller,Shan P Yu,Ling Wei,

Post-ischemia angiogenesis and vascular plasticity help to restore blood flow to ischemic tissue and likely benefit long-term functional recovery. Physical activity has been shown to cause morphologic and functional effects, including promoting angiogenesis in normal or injured animals. A therapeutic effect of peripheral activity on central angiogenesis after cerebral ischemia, however, has not been studied. In the present study of whisker-barrel cortex ischemia in the mouse model, we tested the hypothesis that enhancing whisker activity and sensory input to the ischemic barrel cortex might promote post-ischemia cerebral angiogenesis. Three days after focal ischemia in adult mice, the whiskers corresponding to the ischemic barrel cortex were stimulated by two methods: (1) whiskers on the right side of the mouse face were trimmed away, so the left whiskers were overused by the animals, (2) left whiskers were manually stimulated to enhance input signals to the ischemic barrel cortex. Western blot analysis showed that whisker stimulation increased expression of the angiogenic factors vascular endothelial growth factor, basic fibroblast growth factor, Tie-1, angiopoietin-2 (Ang-2), and possibly Ang-1. Co-immunostaining with markers for proliferation (5-bromo-2'-deoxyuridine (BrdU)) and vascular endothelial cells (Glut-1/CD-31) identified vessel proliferation in the penumbra region. Whisker stimulation increased BrdU-positive endothelial cells and vessels in this region 7 and 14 days after ischemia. Whisker stimulation also attenuated endothelial cell death and increased local cerebral blood flow. Our data suggest that appropriately enhanced peripheral activity and afferent signals to the ischemic cortex can promote post-ischemic angiogenesis, which may imply beneficial effects of specific physical therapy on long-term recovery from ischemic stroke.

Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Publishing Authors By Initials

VR Whitaker,L Cui,S Miller,SP Yu,L Wei,

For similar animal structures: vibrissae research abstracts see: animal structures: vibrissae research

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Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of cerebral blood flow and metabolism : of

VOLUME: 27

Page Numbers: 57-68

Journal Abbreviation: J. Cereb. Blood Flow Metab.

ISSN: 0271-678X

DAY: 3

MONTH: 05

YEAR: 2006

Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8112566

Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Keywords Mesh Terms:

KEYWORDS: Vibrissae

MESH TERMS: physiology

Chemical & Substance for Abstract: Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice. Information

Substance Name: Electron Transport Complex IV

Registry Number: EC 1.9.3.1

Grant and Affiliation Information for Whisker stimulation enhances angiogenesis in the barrel cortex following focal ischemia in mice.

AFFILIATION: Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS 37372

ACRONYM: NS

MEDLINETA: J Cereb Blood Flow Metab

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