When it comes to opiates, just say NO.

When it comes to opiates, just say NO. Research Abstract Details 

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When it comes to opiates, just say NO. Abstract Text:

Gavril W Pasternak,Gavril W Pasternak,

Repeated use of opiate analgesic drugs such as morphine for the relief of chronic pain may result in the development of opiate tolerance and dependence, leading to a narrowing of the drug's therapeutic index and increased side effects. Previous preclinical work has shown that interruption of a signaling cascade involving the N-methyl-D-aspartate receptor and NO prevents morphine tolerance. In this issue of the JCI, Muscoli and colleagues extend our understanding of the role of NO in tolerance by demonstrating that, in mice, tolerance to chronic morphine administration is associated with NO conversion to peroxynitrite, which accumulates and nitrates tyrosine moieties within various proteins in the spinal cord (see the related article beginning on page 3530). This and other data suggest that peroxynitrite plays a role in opiate tolerance and that regulation of peroxynitrite may be utilized for the management of opiate-induced tolerance.

When it comes to opiates, just say NO. Publishing Authors By Initials

GW Pasternak,GW Pasternak,

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When it comes to opiates, just say NO. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 3185-7

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 2

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7802877

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AFFILIATION: Department of Neurology and The Molecular Pharmacology and Chemistry Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. pasterng@mskcc.org

Country: United States

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MEDLINETA: J Clin Invest

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