When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat.

When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Research Abstract Details 

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When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Abstract Text:

Katie R Famous,Heath D Schmidt,R Christopher Pierce,

Nucleus accumbens glutamate transmission plays a critical role in cocaine priming-induced reinstatement of drug seeking. Previous studies have demonstrated that systemic or intra-accumbens shell administration of an NMDA receptor antagonist reinstates cocaine-seeking behavior. However, it is unclear if antagonizing NMDA receptors in the nucleus accumbens core or shell subregions will differentially affect cocaine reinstatement. To investigate this possibility, we microinjected the competitive NMDA receptor antagonist AP-5 (0, 3 or 30 microg) into either the nucleus accumbens core or shell and assessed the reinstatement of cocaine-seeking behavior. When microinjected into the shell, both doses of AP-5 produced reinstatement of cocaine seeking. In contrast, when administered into the core, only the highest dose of AP-5 reinstated cocaine-seeking behavior; moreover, the magnitude of this effect was substantially less than when AP-5 was administered into the shell. This study provides evidence that pharmacological antagonism of NMDA receptors in the nucleus accumbens core or shell promotes the reinstatement of cocaine seeking.

When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Publishing Authors By Initials

KR Famous,HD Schmidt,RC Pierce,

For similar pathological conditions, signs and symptoms: pathologic processes: disease attributes: recurrence research abstracts see: pathological conditions, signs and symptoms: pathologic processes: disease attributes: recurrence research

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When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience letters

VOLUME: 420

Page Numbers: 169-73

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 3

MONTH: 05

YEAR: 2007

When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Keywords Mesh Terms:

KEYWORDS: Recurrence

MESH TERMS: metabolism

Chemical & Substance for Abstract: When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat. Information

Substance Name: 2-Amino-5-phosphonovalerate

Registry Number: 76726-92-6

Grant and Affiliation Information for When administered into the nucleus accumbens core or shell, the NMDA receptor antagonist AP-5 reinstates cocaine-seeking behavior in the rat.

AFFILIATION: Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA. krfamous@bu.edu

Country: Ireland

AGENCY: United States NIGMS

GRANT: T32 GM008541-7

ACRONYM: GM

MEDLINETA: Neurosci Lett

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