West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Research Abstract Details 

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West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Abstract Text:

The complement system, by virtue of its dual effector and priming functions, is a major host defense against pathogens. Flavivirus nonstructural protein (NS)-1 has been speculated to have immune evasion activity, because it is a secreted glycoprotein, binds back to cell surfaces, and accumulates to high levels in the serum of infected patients. Herein, we demonstrate an immunomodulatory function of West Nile virus NS1. Soluble and cell-surface-associated NS1 binds to and recruits the complement regulatory protein factor H, resulting in decreased complement activation in solution and attenuated deposition of C3 fragments and C5b-9 membrane attack complexes on cell surfaces. Accordingly, extracellular NS1 may function to minimize immune system targeting of West Nile virus by decreasing complement recognition of infected cells.

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Publishing Authors By Initials

For similar viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research abstracts see: viruses: rna viruses: flaviviridae: flavivirus: encephalitis viruses, japanese: west nile virus research

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West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 19111-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 28

MONTH: 11

YEAR: 2006

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Keywords Mesh Terms:

KEYWORDS: West Nile virus

MESH TERMS: metabolism

Chemical & Substance for Abstract: West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. Information

Substance Name: Complement Factor I

Registry Number: EC 3.4.21.45

Grant and Affiliation Information for West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H.

AFFILIATION: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NIAID

GRANT: U54 AI 057160

ACRONYM: AI

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE: Proc Natl Acad Sci U S A. 2006 Dec 12;10

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