Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen.

Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Research Abstract Details 

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Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Abstract Text:

Tsutomu Kouno,Masashi Ando,Kan Yonemori,Koji Matsumoto,Chikako Shimizu,Noriyuki Katsumata,Motokiyo Komiyama,Eijiro Okajima,Naoki Matsuoka,Hiroyuki Fujimoto,Yasuhiro Fujiwara,

OBJECTIVE: Weekly administration of paclitaxel plus carboplatin is hypothesized to be an effective second-line treatment for advanced transitional cell cancer after failure of platinum-based regimen. In this phase 2 trial, we tested this hypothesis. PATIENTS AND METHODS: Patients with advanced transitional cell cancer who showed evidence of progressive or recurrent disease after methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) therapy were eligible for this study. Weekly paclitaxel (80mg/m(2)) and carboplatin (AUC 2) were administered on days 1, 8, 15, 22, 29, and 36; the cycle was repeated every 7 wk until disease progression or intolerable toxicity (maximum 18 doses). RESULTS: Thirty-five patients entered this study. Among the 31 patients who were assessable, 10 had an objective response (overall response rate: 32.3%, 95% confidence interval, 15.8-48.7%). The median progression-free survival (PFS) and median survival times were 3.7 and 7.9 mo, respectively. Among the 22 patients who received prior MVAC therapy for metastatic disease, 36% had an objective response; their median PFS and median survival times were 4.3 and 7.9 mo, respectively; neither survival time significantly differed from the survival time of those who received prior MVAC as adjuvant setting. Toxicities were mild except one toxic death due to neutropenic sepsis. CONCLUSIONS: Weekly paclitaxel plus carboplatin was a manageable, active second-line treatment for advanced transitional cell cancer after failure of platinum-based therapy.

Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Publishing Authors By Initials

T Kouno,M Ando,K Yonemori,K Matsumoto,C Shimizu,N Katsumata,M Komiyama,E Okajima,N Matsuoka,H Fujimoto,Y Fujiwara,

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Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European urology

VOLUME: 52

Page Numbers: 1115-22

Journal Abbreviation: Eur. Urol.

ISSN: 0302-2838

DAY: 5

MONTH: 04

YEAR: 2007

Weekly paclitaxel and carboplatin against advanced transitional cell cancer after failure of a platinum-based regimen. Information

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LANGUAGE: eng

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AFFILIATION: Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan. tkouno@ncc.go.jp

Country: Switzerland

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MEDLINETA: Eur Urol

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