Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers.

Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Research Abstract Details 

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Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Abstract Text:

B C Shin,N Wisniewski,W M Reichert,

This study employed two water-soluble and nontoxic molecules, sucrose and glycerol, to enhance the permeability of PEG-PHEMA polymer gels coated onto 100 kDa molecular weight cutoff polyethersulfone (PES) microdialysis probes. Sucrose precoating of the probes prior to prepolymer coating prevented penetration of the prepolymer into the microdialysis membrane. Glycerol mixed with the prepolymer introduced porosity in the polymer coating upon curing. The sucrose and glycerol were completely removed by soaking in PBS after curing of the polymer coat on the probe tip. Polymer coated probe glucose permeability was tested by measuring glucose recovery from PBS solutions. Biocompatibility was assessed by measuring glucose recovery of polymer coated probes from heparanized whole porcine blood. Results show that the sucrose and glycerol treatments yielded polymer coated probes with glucose permeability nearly equal to bare probes when tested in PBS solution, but that this increased permeability was not observed when tested in whole blood. This suggests that the thickness of the polymer films (10-100 microm), while not a limiting factor in PBS solution, may have presented a diffusion barrier to glucose recovered from blood. Surprisingly, however, the polymer coated probes exhibited less thrombus formation that did the bare probes after blood exposure.

Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Publishing Authors By Initials

BC Shin,N Wisniewski,WM Reichert,

For similar water research abstracts see: water research

PUBMED ID PMID:

MEDLINE DATE:

Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 12

Page Numbers: 467-77

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2001

Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers. Information

Substance Name: Water

Registry Number: 7732-18-5

Grant and Affiliation Information for Water-soluble treatments to enhance glucose permeability of protein-resistant polymer overlayers.

AFFILIATION: Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Country: Netherlands

AGENCY: United States NIDDK

GRANT: DK 54932

ACRONYM: DK

MEDLINETA: J Biomater Sci Polym Ed

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