Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Abstract Text:

Jun Wu,Xuefen Wang,Jong Kahk Keum,Hongwen Zhou,Mikhail Gelfer,Carlos-Alberto Avila-Orta,Hui Pan,Weiliam Chen,Shu-Min Chiao,Benjamin S Hsiao,Benjamin Chu,

Novel water soluble, biocompatible, and highly viscoelastic polyelectrolyte complexes were prepared by mixing of positively charged chitosan grafted with poly (ethylene glycol) monomethyl ether (CS-g-MPEG) and negatively charged hyaluronic acid (HA). CS-g-MPEGs having different degrees of substitution were synthesized by reacting chitosan with MPEG-aldehyde. The molecular structure, thermal and rheological properties, as well as biocompatibility of CS-g-MPEG/HA complexes were characterized. Rheological results showed that a small amount of HA could greatly enhance the viscosity of CS-g-MPEG solution. The highest viscosity was obtained when the charge ratio of CS-g-MPEG/HA was close to 1.0. Small-angle X-ray scattering measurements provided some insights into the lamellar structure of the CS-g-MPEG/HA complex. The CS-g-MPEG/HA complex system offers promising potentials in pharmaceutical, cosmetic, and biotechnology applications (e.g., cell scaffold, artificial synovial fluid, and drug/gene delivery medium).

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Publishing Authors By Initials

J Wu,X Wang,JK Keum,H Zhou,M Gelfer,CA Avila-Orta,H Pan,W Chen,SM Chiao,BS Hsiao,B Chu,

For similar water research abstracts see: water research

PUBMED ID PMID:

MEDLINE DATE:

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biomedical materials research. Part A

VOLUME: 80

Page Numbers: 800-12

Journal Abbreviation:

ISSN: 1549-3296

DAY: 15

MONTH: Mar

YEAR: 2007

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Keywords Mesh Terms:

KEYWORDS: Water

MESH TERMS: chemistry

Chemical & Substance for Abstract: Water soluble complexes of chitosan-g-MPEG and hyaluronic acid. Information

Substance Name: Chitosan

Registry Number: 9012-76-4

Grant and Affiliation Information for Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.

AFFILIATION: Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM63283-02

ACRONYM: GM

MEDLINETA: J Biomed Mater Res A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Water soluble complexes of chitosan-g-MPEG and hyaluronic acid Related Publications

• A deficient TLR2 signaling promotes airway mucin production in Mycoplasma pneumoniae-infected allergic mice.
• An image-based approach to measure the ferric ion diffusion coefficient in fricke gel dosimetry.
• Assays for nonhomologous end joining in extracts.
• Backpropagation Neural Network for Motion Analysis on Blood-pool Gated Single Photon Emission Computed Tomography.
• Determination of reaction intermediate structures in heme proteins.
• Differential expression of MUC1, MUC2, and MUC5AC in carcinomas of various sites: an immunohistochemical study.
• EUS could detect ascites missed by CT scan.
• Effects of growth factors on cell migration and alkaline phosphatase release.
• Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides.
• Familial resemblance of adiposity-related parameters: results from a health check-up population in Taiwan.
• Heterogeneous reactions of SO2 with HOCl and HOBr on ice surfaces.
• IL-23-dependent IL-17 production is essential in neutrophil recruitment and activity in mouse lung defense against respiratory Mycoplasma pneumoniae infection.
• MUC1, MUC2 and MUC5AC expressions in cardiac myxoma.
• Measuring the folding transition time of single RNA molecules.
• Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases.
• PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity.
• Scale-up development of high-performance polymer matrix for DNA sequencing analysis.
• Synthesis of neplanocin F analogues as potential antiviral agents.
• Water soluble complexes of chitosan-g-MPEG and hyaluronic acid.
• [Calpain I inhibition prevents pacing-induced structural remodeling for atrial fibrillation in canine]
• [Coronary artery atherosclerotic plaque and stent visualizations by optical coherence tomography]
• [Correlation between the serum levels of interleukin-2 and soluble interleukin-2 receptor and the response to immunosuppressive therapy in severe aplastic anemia patients]
• [Dynamic changes and significance of serum TNF-alpha, IL-8 levels in patients with acute respiratory distress syndrome after severe trauma]
• [Irinotecan plus cisplatin for the treatment of advanced non-small cell lung cancer]
• [Lead expelling effect of carboxymethyl chitosan calcium in lead poisoned mice]
• [Natural killer-like T-cell lymphoma/leukemia--a case report and literature review]
• [Phase I/II clinical trial of weekly administration of docetaxel plus cisplatin for advanced non-small cell lung cancer]
• [Polymorphism of HLA-DRB1 in Han population in Yunnan and comparison with 9 Han populations]
• [Risk factors for postoperative gastroparesis syndrome after pancreaticoduodenectomy with binary logistic regression.]
• [Visualization of intimal proliferation of drug-eluting stent and bare mental stent by use of optical coherence tomography]