A novel technique of simultaneous peptide enrichment and wash-free in-situ self-desalting for MALDI analysis is reported, where a newly synthesized block copolymer with a microphase-separated configuration is applied to embed salts with its hydrophilic domain of poly(ethylene oxide) and concentrate peptides with its hydrophobic domain of polysulfone.
Wash-free in-situ self-desalting and peptide enrichment by block copolymer analyzed with MALDI-TOFMS. Publishing Authors By Initials