Voxel-based morphometry in autopsy proven PSP and CBD.

Voxel-based morphometry in autopsy proven PSP and CBD. Research Abstract Details 

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Voxel-based morphometry in autopsy proven PSP and CBD. Abstract Text:

Keith A Josephs,Jennifer L Whitwell,Dennis W Dickson,Bradley F Boeve,David S Knopman,Ronald C Petersen,Joseph E Parisi,Clifford R Jack,Keith A Josephs,Jennifer L Whitwell,Dennis W Dickson,Bradley F Boeve,David S Knopman,Ronald C Petersen,Joseph E Parisi,Clifford R Jack,

The aim of this study was to compare the patterns of grey and white matter atrophy on MRI in autopsy confirmed progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), and to determine whether the patterns vary depending on the clinical syndrome. Voxel-based morphometry was used to compare patterns of atrophy in 13 PSP and 11 CBD subjects and 24 controls. PSP and CBD subjects were also subdivided into those with a dominant dementia or extrapyramidal syndrome. PSP subjects showed brainstem atrophy with involvement of the cortex and underlying white matter. Frontoparietal grey and subcortical grey matter atrophy occurred in CBD. When subdivided, PSP subjects with an extrapyramidal syndrome had more brainstem atrophy and less cortical atrophy than CBD subjects with an extrapyramidal syndrome. PSP subjects with a dementia syndrome had more subcortical white matter atrophy than CBD subjects with a dementia syndrome. These results show regional differences between PSP and CBD that are useful in predicting the underlying pathology, and help to shed light on the in vivo distribution of regional atrophy in PSP and CBD.

Voxel-based morphometry in autopsy proven PSP and CBD. Publishing Authors By Initials

KA Josephs,JL Whitwell,DW Dickson,BF Boeve,DS Knopman,RC Petersen,JE Parisi,CR Jack,KA Josephs,JL Whitwell,DW Dickson,BF Boeve,DS Knopman,RC Petersen,JE Parisi,CR Jack,

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Voxel-based morphometry in autopsy proven PSP and CBD. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 29

Page Numbers: 280-9

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 13

MONTH: 11

YEAR: 2006

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LANGUAGE: eng

NlmUniqueID: 8100437

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Grant and Affiliation Information for Voxel-based morphometry in autopsy proven PSP and CBD.

AFFILIATION: Department of Neurology (Movement Disorders), Mayo Clinic, Rochester, MN 55905, USA. josephs.keith@mayo.edu

Country: United States

AGENCY: United States NIA

GRANT: U01 AG06786

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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