Voxel-based analysis of R2* maps in the healthy human brain.

Voxel-based analysis of R2* maps in the healthy human brain. Research Abstract Details 

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Voxel-based analysis of R2* maps in the healthy human brain. Abstract Text:

Patrice ,Gisela Hagberg,Giacomo Luccichenti,Andrea Cherubini,Valentina Brainovich,Pierre Celsis,Carlo Caltagirone,Umberto Sabatini,Patrice ,Gisela Hagberg,Giacomo Luccichenti,Andrea Cherubini,Valentina Brainovich,Pierre Celsis,Carlo Caltagirone,Umberto Sabatini,

PURPOSE: To develop a voxel-based analysis of an R2* map of healthy human brain that is automatic, reproducible, and realizable in a single examination on a 3T MR imager. Such a tool could be useful to measure iron accumulation in neurodegenerative diseases. MATERIALS AND METHODS: In all, 18 healthy subjects underwent MR imaging at a field strength of 3T: 1) six consecutive T2*-weighted gradient-echo volumes were acquired using a segmented echo-planar imaging sequence and 2) a conventional dual-echo turbo spin echo sequence was also applied to acquire T2-weighted images. Images were realigned and spatial correction was performed using a template brain dataset with SPM2. For each subject we performed a voxel-by-voxel nonlinear least-squares fitting of the data acquired at the six echo times to obtain a monoexponential signal decay curve. The reproducibility and sensitivity to age variation were assessed by voxel-based analysis. RESULTS: The reproducibility tests in whole brain analysis showed little R2* variation. Furthermore, the statistical analysis, performed on each brain voxel, revealed a significant positive correlation between age and MR values located in regions where a slow and constant age-related iron deposition is known. CONCLUSION: Our method, combining data acquisition and data processing, demonstrates the feasibility of voxel-based analysis on an R2* map and affords a high degree of sensitivity and good reproducibility while maintaining high spatial resolution. J. Magn. Reson. Imaging 2007. (c) 2007 Wiley-Liss, Inc.

Voxel-based analysis of R2* maps in the healthy human brain. Publishing Authors By Initials

P ,G Hagberg,G Luccichenti,A Cherubini,V Brainovich,P Celsis,C Caltagirone,U Sabatini,P ,G Hagberg,G Luccichenti,A Cherubini,V Brainovich,P Celsis,C Caltagirone,U Sabatini,

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Voxel-based analysis of R2* maps in the healthy human brain. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of magnetic resonance imaging : JMRI

VOLUME: 26

Page Numbers: 1413-20

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ISSN: 1053-1807

DAY: 10

MONTH: Dec

YEAR: 2007

Voxel-based analysis of R2* maps in the healthy human brain. Information

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LANGUAGE: eng

NlmUniqueID: 9105850

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AFFILIATION: Department of Neuroradiology, I.R.C.C.S. Foundation Santa Lucia, Italy.

Country: United States

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MEDLINETA: J Magn Reson Imaging

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