Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens.

Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Research Abstract Details 

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Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Abstract Text:

William C Griffin,Lawrence D Middaugh,Howard C Becker,

The present study determined ethanol concentrations in the nucleus accumbens (NAcc) of C57BL/6J (B6) mice voluntarily drinking ethanol using an established limited access paradigm. Lickometer circuits were employed to monitor the temporal pattern of consummatory behavior, and serial samples were collected from the NAcc using in vivo microdialysis techniques. Ethanol in the dialysate was measured by gas chromatography with flame ionization detection. During dialysis, mice preferentially consumed sufficient amounts of sweetened ethanol ( approximately 3 g/kg ethanol) to produce low millimolar levels of ethanol in dialysates from the NAcc; water intake was negligible. Overall, there was a positive relationship between total amount of ethanol consumed during the 2 h drinking session and cumulative (as well as peak) ethanol levels in NAcc. Additionally, and the total number of licking responses was positively correlated with the total amount of ethanol consumed. Moreover, the change in NAcc ethanol levels was temporally linked to the pattern of ethanol drinking, with periods of high licking responses on the ethanol tube preceding peak brain ethanol levels. The results indicate that the voluntary consumption of ethanol by B6 mice in a limited access time frame elevates ethanol concentration in NAcc dialysates in a manner consistent with the pattern of ethanol consumption.

Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Publishing Authors By Initials

WC Griffin,LD Middaugh,HC Becker,

For similar therapeutics: drug therapy: self administration research abstracts see: therapeutics: drug therapy: self administration research

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Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Brain research

VOLUME: 1138

Page Numbers: 208-13

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 29

MONTH: 12

YEAR: 2006

Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Keywords Mesh Terms:

KEYWORDS: Self Administration

MESH TERMS: metabolism

Chemical & Substance for Abstract: Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Voluntary ethanol drinking in mice and ethanol concentrations in the nucleus accumbens.

AFFILIATION: Charleston Alcohol Research Center, Center for Drug and Alcohol Programs, PO Box 250861, Medical University of South Carolina, Charleston, SC 29425-0742, USA. griffinw@musc.edu

Country: Netherlands

AGENCY: United States NIAAA

GRANT: P50AA10761

ACRONYM: AA

MEDLINETA: Brain Res

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