Voltammetric determination of nitrosocimetidine in simulated gastric juice.

Voltammetric determination of nitrosocimetidine in simulated gastric juice. Research Abstract Details 

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Voltammetric determination of nitrosocimetidine in simulated gastric juice. Abstract Text:

OBJECTIVE: To develop a voltammetric method for the determination of nitrosocimetidine in simulated gastric juice (SGJ). METHOD: Measurement of the polarographic wave of the nitroso derivative at the dropping mercury electrode in 0.1 m HCl. RESULTS: A well-defined diffusion-controlled cathodic wave was obtained at -0.34 V vs. Ag/AgCl electrode. The current-concentration relationship was found to be rectilinear over the range 10-80 microg/mL and 2-50 microg/mL with percentage recovery of 101.24 +/- 0.79 and 100.79 +/- 0.56 for the direct current (DCt) and differential pulse polarography (DPP) modes, respectively, with a minimum detectability (S/N=2) of 0.16 microg/ml (5.6 x 10-7 m) using DPP mode. CONCLUSION: The proposed method was successfully applied to study the nitrosation of cimetidine in SGJ.

Voltammetric determination of nitrosocimetidine in simulated gastric juice. Publishing Authors By Initials

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Voltammetric determination of nitrosocimetidine in simulated gastric juice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 27

Page Numbers: 365-70

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Oct

YEAR: 2002

Voltammetric determination of nitrosocimetidine in simulated gastric juice. Information

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LANGUAGE: eng

NlmUniqueID: 8704308

Voltammetric determination of nitrosocimetidine in simulated gastric juice. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: methods

Chemical & Substance for Abstract: Voltammetric determination of nitrosocimetidine in simulated gastric juice. Information

Substance Name: nitrosocimetidine

Registry Number: 73785-40-7

Grant and Affiliation Information for Voltammetric determination of nitrosocimetidine in simulated gastric juice.

AFFILIATION: Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt. manaleid@mum.mans.eun.eg

Country: England

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MEDLINETA: J Clin Pharm Ther

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