VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage.

VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Research Abstract Details 

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VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Abstract Text:

Michal Mielcarek,Stefan ,Marcus ,Thomas Braun,

In order to identify novel genes expressed in skeletal muscle we performed a subtractive hybridization for genes expressed in human skeletal muscle but not in other tissues. We identified a novel scalloped interaction domain (SID) containing protein in humans and in the mouse, which we named VITO-1. Highest homology of VITO-1 was found with the Drosophila vestigial and the human TONDU proteins in the SID (54 and 40%, respectively). Using whole-mount hybridzation and Northern blot analysis, we showed that VITO-1 is expressed in the somitic myotome from E8.75 mouse embryos onwards and later on in skeletal muscle but not in the heart. Additional expression domains during development were detected in the pharyngeal pouches and clefts starting at E8.0 as well as in the cranial pharynx and in Rathkes pouch. By Northern blot analysis, we found VITO-1 to be up-regulated in C2C12 myotubes although some expression can be detected in proliferating C2C12 myoblasts. No expression was spotted in other adult mouse tissues. Likewise, expression of human Vito-1 during fetal and adult human development was found exclusively in skeletal muscle preferentially in fast skeletal muscles. These data suggest a role of VITO-1 for the development of skeletal muscles and of pharyngeal clefts/Rathkes' pouch derived structures.

VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Publishing Authors By Initials

M Mielcarek,S ,M ,T Braun,

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VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mechanisms of development

VOLUME: 119 Suppl 1

Page Numbers: S269-74

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 30

MONTH: Dec

YEAR: 2002

VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage. Information

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LANGUAGE: eng

NlmUniqueID: 9101218

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Grant and Affiliation Information for VITO-1, a novel vestigial related protein is predominantly expressed in the skeletal muscle lineage.

AFFILIATION: Institute of Physiological Chemistry, University of Halle-Wittenberg, Hollystrasse 1, 06097 Halle, Germany.

Country: Ireland

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MEDLINETA: Mech Dev

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