Vitamin E supplementation does not improve survival from infection in mice when given after burn injury.

Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Research Abstract Details 

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Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Abstract Text:

M D Peck,J W Alexander,

Previous studies have shown that vitamin E acetate given by gavage to mice before thermal injury can improve survival from subsequent infection. We tested the efficacy of aqueous vitamin E given parenterally after burn injury. Female BALB/c mice (n = 120) were given 15% total body surface area full-thickness flame burns. Three groups of mice were randomized to receive water-miscible vitamin E with the resuscitation fluid in doses of 0.5 mg per mouse, 0.167 mg per mouse, or 0.056 mg per mouse. These doses represented approximately nine, three, and one times the murine recommended daily allowance for vitamin E, respectively. Control mice were given saline only. The next day the mice were challenged with 2.5 x 10(5) Pseudomonas aeruginosa beneath the eschar. Administration of vitamin E was continued on a daily basis for a total of three doses and ending the day after bacterial challenge. Mortality rates were observed for 1 week and were not statistically different among the four groups. We conclude that vitamin E supplementation started after thermal injury in mice does not improve outcome from subsequent challenge with Pseudomonas aeruginosa.

Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Publishing Authors By Initials

MD Peck,JW Alexander,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

PUBMED ID PMID:

MEDLINE DATE: 1991 Jan-Feb

Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of burn care & rehabilitation

VOLUME: 12

Page Numbers: 41-2

Journal Abbreviation:

ISSN: 0273-8481

DAY: 19

MONTH: 11

YEAR: 2007

Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8110188

Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Vitamin E supplementation does not improve survival from infection in mice when given after burn injury. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Vitamin E supplementation does not improve survival from infection in mice when given after burn injury.

AFFILIATION: Shriners Burns Institute, Cincinnati, Ohio.

Country: UNITED STATES

AGENCY: United States NIAID

GRANT: AI12936

ACRONYM: AI

MEDLINETA: J Burn Care Rehabil

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