Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model.

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Research Abstract Details 

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Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Abstract Text:

V M Factor,D Laskowska,M R Jensen,J T Woitach,N C Popescu,S S Thorgeirsson,

We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible for the extensive chromosomal damage and acceleration of hepatocarcinogenesis characteristic for TGFalpha/c-myc mice. In this study, we show that vitamin E (VE), a potent free radical scavenging antioxidant, is able to protect liver tissue against oxidative stress and suppress tumorigenic potential of c-myc oncogene. Dietary supplementation with VE, starting from weaning, decreased ROS generation coincident with a marked inhibition of hepatocyte proliferation while increasing the chromosomal as well as mtDNA stability in the liver. Similarly, dietary VE reduced liver dysplasia and increased viability of hepatocytes. At 6 mo of age, VE treatment decreased the incidence of adenomas by 65% and prevented malignant conversion. These results indicate that ROS generated by over-expression of c-myc and TGFalpha in the liver are the primary carcinogenic agents in this animal model. Furthermore, the data demonstrate that dietary supplementation of VE can effectively inhibit liver cancer development.

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Publishing Authors By Initials

VM Factor,D Laskowska,MR Jensen,JT Woitach,NC Popescu,SS Thorgeirsson,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 97

Page Numbers: 2196-201

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 29

MONTH: Feb

YEAR: 2000

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: analogs & derivatives

Chemical & Substance for Abstract: Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model. Information

Substance Name: tocopherol acetate

Registry Number: 7695-91-2

Grant and Affiliation Information for Vitamin E reduces chromosomal damage and inhibits hepatic tumor formation in a transgenic mouse model.

AFFILIATION: Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA.

Country: UNITED STATES

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MEDLINETA: Proc Natl Acad Sci U S A

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