Vitamin E inhibits melanoma growth in mice.

Vitamin E inhibits melanoma growth in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Vitamin E inhibits melanoma growth in mice. Abstract Text:

Mokenge P Malafa,Frida D Fokum,Arian Mowlavi,Mary Abusief,Michele King,

BACKGROUND: Previous work has demonstrated that vitamin E succinate (VES), an ester analogue of vitamin E, inhibits the growth of melanoma in vitro. However, there is no information about the effect of VES on melanoma in vivo. We investigated the effect of VES on melanoma in vitro and in vivo. METHODS: The effect of VES on the proliferation and apoptosis of the B16F10 murine melanoma cell line was determined by a modified Cell Titer 96 AQ assay and a cell death detection enzyme-linked immunosorbent assay, respectively. The in vivo effect of VES on B16F10 melanoma cells allografted in athymic nude mice was investigated. The mechanism of the in vivo antitumor effect of VES was determined by immunohistochemical detection of proliferation and apoptosis. RESULTS: VES decreased cell proliferation (P =.0001) and increased cell apoptosis (P =.0001) in a dose-dependent manner in vitro. Also, VES significantly inhibited melanoma growth in mice (P =.0013). The VES antitumor effect in vivo was associated with a significant increase in the melanoma apoptosis rate (P =.0256). CONCLUSIONS: This is the first report of the antimelanoma effect of VES in vivo. The mechanism of the antimelanoma effect of VES in vivo involves the promotion of tumor cell apoptosis. These findings support future investigations of VES as a therapeutic micronutrient against melanoma.

Vitamin E inhibits melanoma growth in mice. Publishing Authors By Initials

MP Malafa,FD Fokum,A Mowlavi,M Abusief,M King,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

PUBMED ID PMID:

MEDLINE DATE:

Vitamin E inhibits melanoma growth in mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Surgery

VOLUME: 131

Page Numbers: 85-91

Journal Abbreviation: Surgery

ISSN: 0039-6060

DAY: 19

MONTH: Jan

YEAR: 2002

Vitamin E inhibits melanoma growth in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 417347

Vitamin E inhibits melanoma growth in mice. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Vitamin E inhibits melanoma growth in mice. Information

Substance Name: tocopherol succinate

Registry Number: 17407-37-3

Grant and Affiliation Information for Vitamin E inhibits melanoma growth in mice.

AFFILIATION: Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL 62794-9638, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Surgery

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Vitamin E inhibits melanoma growth in mice Related Publications

• A satisfaction enhancement intervention for long-term weight loss.
• A systematic literature review of tobacco use among adults 15 years and older in sub-Saharan Africa.
• Coloring our eyes.
• Computational study of the contribution of the vasculature on the dynamic response of the brain.
• Cytogenetic analysis of Day-4 embryos from PMSG/hCG-treated prepuberal gilts.
• Death by survey: estimating adult mortality without selection bias from sibling survival data.
• Dynamic regulation of single- and mixed-species malaria infection: insights to specific and non-specific mechanisms of control.
• Early recurrence of an intracranial epidermoid cyst due to low-grade infection: case report.
• Factors that shape young people's sexual behaviour: a systematic review.
• Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding.
• Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).
• Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.
• Impacting policy through science and education.
• Incorporation of system resolution compensation (RC) in the ordered-subset transmission (OSTR) algorithm for transmission imaging in SPECT.
• Mechanical characterization of porcine abdominal organs.
• Morphological study of the bovine blastocyst with phase contrast microscopy.
• Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy.
• Progesterone and luteinizing hormone profiles in heifers used as oocyte donors.
• Reduction in antimicrobial substantivity of MTAD after initial sodium hypochlorite irrigation.
• Regio- and stereospecific syntheses and nitric oxide donor properties of (E)-9- and (E)-10-nitrooctadec-9-enoic acids.
• Reproductive performance of Polwarth and corriedale sheep in Tasmania.
• Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime.
• Streptomycin and dihydrostreptomycin; applied pharmacology.
• Stress versus discrete negative emotions in the prediction of physical complaints: does predictive utility vary across ethnic groups?
• Structural Response of Lower Leg Muscles in Compression: A Low Impact Energy Study Employing Volunteers, Cadavers and the Hybrid III.
• The impact of group size on memory and memory beliefs: a methodological report.
• The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration.
• Tourette syndrome: the self under siege.
• Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT.
• Vitamin E inhibits melanoma growth in mice.