Vitamin E imaging and localization in the neuronal membrane.

Vitamin E imaging and localization in the neuronal membrane. Research Abstract Details 

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Vitamin E imaging and localization in the neuronal membrane. Abstract Text:

Eric B Monroe,John C Jurchen,Jinju Lee,Stanislav S Rubakhin,Jonathan V Sweedler,

Vitamin E (alpha-tocopherol) has been implicated in several cellular processes including signaling, transport, lipid membrane curvature, and several neurodegenerative disorders. Vitamin E imaging has been hindered by the inaccessibility of the molecule to traditional immunohistochemical methods. Using time-of-flight secondary ion mass spectrometry (ToF-SIMS), the distribution of major constituents in the cellular membrane of isolated neurons was investigated. There is a significant increase in the vitamin E signal at the soma-neurite junction compared to the cell as a whole (165 +/- 11% of that found across the cell, p = 0.004, n = 12). The observed membrane distribution suggests an important new role for vitamin E in neuronal function.

Vitamin E imaging and localization in the neuronal membrane. Publishing Authors By Initials

EB Monroe,JC Jurchen,J Lee,SS Rubakhin,JV Sweedler,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Vitamin E imaging and localization in the neuronal membrane. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 12152-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 7

MONTH: Sep

YEAR: 2005

Vitamin E imaging and localization in the neuronal membrane. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Vitamin E imaging and localization in the neuronal membrane. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Vitamin E imaging and localization in the neuronal membrane. Information

Substance Name: Vitamin E

Registry Number: 1406-18-4

Grant and Affiliation Information for Vitamin E imaging and localization in the neuronal membrane.

AFFILIATION: Department of Chemistry and the Beckman Institute, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

Country: United States

AGENCY: United States NIDA

GRANT: P30DA018310

ACRONYM: DA

MEDLINETA: J Am Chem Soc

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