Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study.

Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Research Abstract Details 

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Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Abstract Text:

Kazutoshi Nakamura,Naoko Tsugawa,Toshiko Saito,Miki Ishikawa,Yasuo Tsuchiya,Keiko Hyodo,Keiko Maruyama,Rieko Oshiki,Ryosaku Kobayashi,Mitsue Nashimoto,Akihiro Yoshihara,Reo Ozaki,Toshio Okano,Masaharu Yamamoto,

Little has been understood about vitamin D status in relation to bone health in Asian women. The purpose of this study was to identify how the serum 25-hydroxyvitamin D (25[OH]D) concentration is associated with bone mass and bone metabolism. This cross-sectional, community-based epidemiologic study was conducted among 600 ambulatory postmenopausal women. The serum 25(OH)D concentration was measured with radioimmunoassay. Other blood biochemical measurements were intact parathyroid hormone and markers of bone turnover, including osteocalcin and type I collagen cross-linked N-telopeptides. Bone mineral density (BMD) of the lumbar spine and right femoral neck were measured with the dual-energy X-ray absorptiometry method using a QDR4500a. The mean serum 25(OH)D concentration was 55.6 nmol/L (SD 14.6). Serum 25(OH)D concentration was linearly associated with BMD of the femoral neck (R(2)=0.020, P=0.003), but not with BMD of the lumbar spine. Odds ratios (ORs) for low BMD (defined as t score /=70 nmol/L). Prevalence of low BMD for the femoral neck was significantly higher in the 30- to 40-nmol/L (adjusted OR=3.6, 95% CI: 1.1-12.1) and the 40- to 50-nmol/L (adjusted OR=7.6, 95% CI: 2.5-23.2) groups compared to the reference group (>/=70 nmol/L). The mean serum concentration of intact PTH was significantly higher in subjects with serum 25(OH)D <50 nmol/L compared to those with serum 25(OH)D >/=50 nmol/L. The present study suggests that higher serum 25(OH)D concentrations are associated with increased BMD of the femoral neck, and that a serum 25(OH)D concentration of at least 70 nmol/L is needed to obtain high BMD of the femoral neck, and that of at least 50 nmol/L is needed to achieve normal PTH levels and prevent low BMD in home-dwelling postmenopausal Japanese women.

Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Publishing Authors By Initials

K Nakamura,N Tsugawa,T Saito,M Ishikawa,Y Tsuchiya,K Hyodo,K Maruyama,R Oshiki,R Kobayashi,M Nashimoto,A Yoshihara,R Ozaki,T Okano,M Yamamoto,

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Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bone

VOLUME: 42

Page Numbers: 271-7

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 10

MONTH: 10

YEAR: 2007

Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Vitamin D status, bone mass, and bone metabolism in home-dwelling postmenopausal Japanese women: Yokogoshi Study.

AFFILIATION: Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan.

Country: United States

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MEDLINETA: Bone

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