Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer.

Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer. Research Abstract Details 

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Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer. Abstract Text:

Tess V Clendenen,Alan A Arslan,Karen L Koenig,Kerstin Enquist,Isaac Wirgin,Sa Gren,Annekatrin Lukanova,Hubert Sjodin,Anne Zeleniuch-Jacquotte,Roy E Shore, Hallmans,Paolo Toniolo,Eva Lundin,Tess V Clendenen,Alan A Arslan,Karen L Koenig,Kerstin Enquist,Isaac Wirgin,Asa Agren,Annekatrin Lukanova,Hubert Sjodin,Anne Zeleniuch-Jacquotte,Roy E Shore, Hallmans,Paolo Toniolo,Eva Lundin,

The vitamin D receptor (VDR) is a critical mediator of the cellular effects of vitamin D. The associations between four common VDR polymorphisms (BSMI, APAI, TAQI, and FOKI) and risk of epithelial ovarian cancer (EOC) were assessed in a case-control study nested within two prospective cohorts. One hundred seventy incident cases of EOC and 323 individually matched controls were genotyped. Overall, no associations were observed in genotype analyses. Haplotypes combining three SNPs in high linkage disequilibrium (BSMI, APAI, and TAQI) were also not associated with risk. These observations do not support a role for BSMI, APAI, TAQI, and FOKI polymorphisms in epithelial ovarian cancer in a predominantly Caucasian population.

Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer. Publishing Authors By Initials

TV Clendenen,AA Arslan,KL Koenig,K Enquist,I Wirgin,S Gren,A Lukanova,H Sjodin,A Zeleniuch-Jacquotte,RE Shore,G Hallmans,P Toniolo,E Lundin,TV Clendenen,AA Arslan,KL Koenig,K Enquist,I Wirgin,A Agren,A Lukanova,H Sjodin,A Zeleniuch-Jacquotte,RE Shore,G Hallmans,P Toniolo,E Lundin,

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Vitamin D receptor polymorphisms and risk of epithelial ovarian cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer letters

VOLUME: 260

Page Numbers: 209-15

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 18

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Environmental Medicine, New York University School of Medicine, New York, NY 10016, USA.

Country: Ireland

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MEDLINETA: Cancer Lett

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