Vitamin D in patients with kidney disease: cautiously optimistic.

Vitamin D in patients with kidney disease: cautiously optimistic. Research Abstract Details 

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Vitamin D in patients with kidney disease: cautiously optimistic. Abstract Text:

Ravi Thadhani,Myles Wolf,

Nephrologists are well aware of the therapeutic effects of activated vitamin D in managing secondary hyperparathyroidism. Beyond bone and mineral metabolism, however, we are now beginning to appreciate the effects of activating the vitamin D receptor (VDR) in other cell types. Our group and others recently found a survival advantage associated with injectable vitamin D therapy in hemodialysis populations. The observational nature of these studies, however, subjects them to the possibility that confounding and bias may have accounted for their results. Therefore, it is unclear if indeed a survival benefit exists, if harm is incurred with this therapy or if activation of the VDR in cell types other than bone, intestine, and the parathyroid gland are applicable to our patients with kidney disease. The range of studies being planned include those targeting the cardiovascular effects of VDR activation, further understanding of the prevalence and consequences of vitamin D deficiency in patients with kidney disease, trials to examine the effects of VDR activation on intermediate cardiovascular and noncardiovascular endpoints, and trials targeting mortality endpoints. If consistent with the recent observations, these studies may provide nephrologists with an intervention to alter the otherwise poor outcomes in patients with kidney disease.

Vitamin D in patients with kidney disease: cautiously optimistic. Publishing Authors By Initials

R Thadhani,M Wolf,

For similar nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin d deficiency research abstracts see: nutritional and metabolic diseases: nutrition disorders: malnutrition: deficiency diseases: avitaminosis: vitamin d deficiency research

PUBMED ID PMID:

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Vitamin D in patients with kidney disease: cautiously optimistic. Journal Published:

PUBLICATION TYPE: Review

Journal: Advances in chronic kidney disease

VOLUME: 14

Page Numbers: 22-6

Journal Abbreviation:

ISSN: 1548-5595

DAY: 3

MONTH: Jan

YEAR: 2007

Vitamin D in patients with kidney disease: cautiously optimistic. Information

Number of References: 38

LANGUAGE: eng

NlmUniqueID: 101209214

Vitamin D in patients with kidney disease: cautiously optimistic. Keywords Mesh Terms:

KEYWORDS: Vitamin D Deficiency

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Vitamin D in patients with kidney disease: cautiously optimistic. Information

Substance Name: Vitamin D

Registry Number: 1406-16-2

Grant and Affiliation Information for Vitamin D in patients with kidney disease: cautiously optimistic.

AFFILIATION: Center for D-receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. rthadhani@partners.org

Country: United States

AGENCY: United States NIDDK

GRANT: DK71674

ACRONYM: DK

MEDLINETA: Adv Chronic Kidney Dis

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