Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children.

Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Research Abstract Details 

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Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Abstract Text:

BACKGROUND: The effect of vitamin A supplementation on viral gastrointestinal infections among young children living in developing countries remains unclear. METHODS: The effect of vitamin A supplementation on norovirus (NoV) infection among 127 Mexican children 5-15 months of age was studied in a randomized, placebo-controlled trial during June-August 1998. Stool samples collected every 2 weeks and after diarrheal episodes were screened for NoV and characterized at the genogroup level (GI and GII). RESULTS: Of the stool samples collected, 29.9% were positive for NoV, and NoV GI and NoV GII were found in 55.4% and 46.4% of the positive samples, respectively. Vitamin A supplementation reduced the prevalence of NoV GII infections (rate ratio [RR], 0.60 [95% confidence interval {CI}, 0.20-0.82]), increased the length of both NoV GI and GII shedding, and decreased the prevalence of NoV-associated diarrhea (RR, 0.51 [95% CI, 0.26-0.97]). CONCLUSIONS: These findings suggest that NoV is an important cause of pediatric diarrhea in this study population and that vitamin A supplementation has divergent effects on specific outcomes of NoV infection.

Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Publishing Authors By Initials

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: growth substances: micronutrients: vitamins research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: growth substances: micronutrients: vitamins research

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Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 196

Page Numbers: 978-85

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 22

MONTH: 08

YEAR: 2007

Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Keywords Mesh Terms:

KEYWORDS: Vitamins

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children. Information

Substance Name: Vitamin A

Registry Number: 11103-57-4

Grant and Affiliation Information for Vitamin A supplementation has divergent effects on norovirus infections and clinical symptoms among Mexican children.

AFFILIATION: Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. k.long@uq.edu.au

Country: United States

AGENCY: United States NIDDK

GRANT: K01 DK06142-02

ACRONYM: DK

MEDLINETA: J Infect Dis

REFSOURCE: J Infect Dis. 2007 Oct 1;196(7):965-7

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