Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine.

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Abstract Text:

J Thongborisute,H Takeuchi,H Yamamoto,Y Kawashima,J Thongborisute,H Takeuchi,H Yamamoto,Y Kawashima,

The objectives of this study were to observe the penetrative and mucoadhesive behavior of polymer-coated liposomes into the intestinal mucosa of rats. Chitosan (CS) and negatively charged liposomes were chosen as model polymer-coated liposomes. In order to observe their behavior, chitosan was labeled with Fluorescence Isothiocyanate (FITC) via chemical reaction at the isothiocyanate group of FITC and the primary amino group of chitosan; the liposomes (Lips) were marked by incorporation of DiI into the liposomal formulation. FITC-labeled chitosan (FITC-CS), Non-Lips, and FITC-labeled CS-coated Liposomes (FITC-CS-Lips) were intragastrically administered into male Wistar rats, and the behavior of the molecules was subsequently visualized by CLSM (Confocal Laser Scanning Microscopy). The results demonstrated that the chitosan molecules themselves, as well as the liposomes, could penetrate across the intestinal mucosa. Moreover, the CLSM images demonstrated a lack of separation of the chitosan molecules from the surface of the liposomes after the administration of chitosan-coated liposomes.

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Publishing Authors By Initials

J Thongborisute,H Takeuchi,H Yamamoto,Y Kawashima,J Thongborisute,H Takeuchi,H Yamamoto,Y Kawashima,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of liposome research

VOLUME: 16

Page Numbers: 127-41

Journal Abbreviation:

ISSN: 0898-2104

DAY: 6

MONTH: 06

YEAR: 2006

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9001952

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine.

AFFILIATION: Department of Pharmaceutical Engineering, Gifu Pharmaceutical University, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Liposome Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine Related Publications

• A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2.
• A novel evaluation method of gastric mucoadhesive property in vitro and the mucoadhesive mechanism of tetracycline-sucralfate acidic complex for eradication of Helicobacter pylori.
• A unique specificity of a calcium activated neutral protease indicated in histone hydrolysis.
• Calpain-calpastatin interactions in epidermoid carcinoma KB cells.
• Changes in cellular levels of ATP and its catabolites in ischemic rat liver.
• Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase.
• Comparison of low and high calcium requiring forms of the calcium-activated neutral protease (CANP) from rabbit skeletal muscle.
• Delivery of immunoprophylactics in transgenic plants: current status.
• Differential inhibition of calpain and proteasome activities by peptidyl aldehydes of di-leucine and tri-leucine.
• Effects of supplemented diacylglycerol rich in docosahexaenoic acid on serum triacylglycerol in a diet-induced hyperlipidemic model of rats are essentially equivalent to those of triacylglycerol rich in docosahexaenoic acid.
• Electronic and optical properties of ladder-type heteraborins.
• Enhanced serum antigen-specific IgG1 and proinflammatory cytokine production in nicotinic acetylcholine receptor alpha7 subunit gene knockout mice.
• Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts.
• Hydrolysis of protamine by calcium-activated neutral protease (CANP).
• Hydrolytic and autolytic behavior of two forms of calcium-activated neutral protease (CANP).
• Imaging of multistep human hepatocarcinogenesis.
• Isolation and characterization of monoclonal antibodies against calcium-activated neutral protease with low calcium sensitivity.
• Large scale isolation of osteoclast-specific genes by an improved method involving the preparation of a subtracted cDNA library.
• Modification of directed-loop algorithm for continuous space simulation of bosonic systems.
• PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts.
• Possible involvement of clathrin in neuritogenesis induced by a protease inhibitor (benzyloxycarbonyl-Leu-Leu-Leu-aldehyde) in PC12 cells.
• Purification and characterization of 210,000-dalton inhibitor of calcium-activated neutral protease from rabbit skeletal muscle and its relation to 50,000-dalton inhibitor.
• Purification and characterization of a calcium-activated neutral protease from rabbit skeletal muscle which requires calcium ions of microM order concentration.
• Purification and characterization of an inhibitor of calcium-activated neutral protease from rabbit skeletal muscle: purification of 50,000-dalton inhibitor.
• Roles of sulfated glycans in lymphocyte homing.
• The Drug Release Profile from Calcium-induced Alginate Gel Beads Coated with an Alginate Hydrolysate.
• The neurite-initiating effect of a tripeptide aldehyde protease inhibitor on PC12h cells.
• VIP induces the translocation and degradation of the alpha subunit of Gs protein in rat pituitary GH4C1 cells.
• Visualization of the penetrative and mucoadhesive properties of chitosan and chitosan-coated liposomes through the rat intestine.
• [Development of gene delivery system using PLGA nanospheres]