Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group.

Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Research Abstract Details 

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Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Abstract Text:

M A Uberall,H Hertzberg,W Meier,T Langer,J D Beck,D Wenzel,M A Uberall,H Hertzberg,W Meier,T Langer,J D Beck,D Wenzel,

Visual-evoked potentials (VEPs) were studied in 92 asymptomatic long-term survivors of acute lymphoblastic leukemia (ALL) in first complete remission 6-7 years after cessation of therapy in order to detect therapy-related disturbances in conduction velocity capacities within central nerve fibers. Subjects were grouped with respect to CNS prophylaxis: a) ith. MTX and 18 GY cranial irradiation (group A, n = 58), b) ith. MTX and iv. MHD-MTX, no cranial irradiation (group B, n = 34). At follow-up VEPs were abnormal in 10 subjects (10.9%) with comparable rates in both CNS prophylaxis groups (A: 7/58 [12.1%], B: 3/34 [8.8%]; p = 0.56). Participants with radiological signs of leukodystrophy (n = 14), all within the irradiated CNS prophylaxis group showed significantly prolonged P100 latencies and had a 6.1-fold increased relative risk to develop VEP disturbances. No correlation could be established between VEP outcome and illness- or treatment-related parameters. VEP outcome was not correlated with age at diagnosis or gender. Thus, VEP recordings showed a close relationship with radiation-induced CNS white-matter disturbances. However, their value for clinical practice, routinely performed follow-up evaluations or standardized posttreatment surveillance studies is negligible.

Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Publishing Authors By Initials

MA Uberall,H Hertzberg,W Meier,T Langer,JD Beck,D Wenzel,MA Uberall,H Hertzberg,W Meier,T Langer,JD Beck,D Wenzel,

For similar persons: patients: survivors research abstracts see: persons: patients: survivors research

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Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Journal Published:

PUBLICATION TYPE: Multicenter Study

Journal: Neuropediatrics

VOLUME: 27

Page Numbers: 194-6

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Aug

YEAR: 1996

Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Information

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LANGUAGE: eng

NlmUniqueID: 8101187

Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Keywords Mesh Terms:

KEYWORDS: Survivors

MESH TERMS: therapy

Chemical & Substance for Abstract: Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group. Information

Substance Name: Methotrexate

Registry Number: 59-05-2

Grant and Affiliation Information for Visual-evoked potentials in long-term survivors of acute lymphoblastic leukemia in childhood. The German Late Effects Working Group.

AFFILIATION: Neuropediatric Department, University Hospital for Children and Adolescents, Erlangen, Germany.

Country: GERMANY

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MEDLINETA: Neuropediatrics

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