Visceral fat adipokine secretion is associated with systemic inflammation in obese humans.

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Research Abstract Details 

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Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Abstract Text:

Luigi Fontana,J Christopher Eagon,Maria E Trujillo,Philipp E Scherer,Samuel Klein,

Although excess visceral fat is associated with noninfectious inflammation, it is not clear whether visceral fat is simply associated with or actually causes metabolic disease in humans. To evaluate the hypothesis that visceral fat promotes systemic inflammation by secreting inflammatory adipokines into the portal circulation that drains visceral fat, we determined adipokine arteriovenous concentration differences across visceral fat, by obtaining portal vein and radial artery blood samples, in 25 extremely obese subjects (mean +/- SD BMI 54.7 +/- 12.6 kg/m(2)) during gastric bypass surgery at Barnes-Jewish Hospital in St. Louis, Missouri. Mean plasma interleukin (IL)-6 concentration was approximately 50% greater in the portal vein than in the radial artery in obese subjects (P = 0.007). Portal vein IL-6 concentration correlated directly with systemic C-reactive protein concentrations (r = 0.544, P = 0.005). Mean plasma leptin concentration was approximately 20% lower in the portal vein than in the radial artery in obese subjects (P = 0.0002). Plasma tumor necrosis factor-alpha, resistin, macrophage chemoattractant protein-1, and adiponectin concentrations were similar in the portal vein and radial artery in obese subjects. These data suggest that visceral fat is an important site for IL-6 secretion and provide a potential mechanistic link between visceral fat and systemic inflammation in people with abdominal obesity.

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Publishing Authors By Initials

L Fontana,JC Eagon,ME Trujillo,PE Scherer,S Klein,

For similar body regions: viscera research abstracts see: body regions: viscera research

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Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Diabetes

VOLUME: 56

Page Numbers: 1010-3

Journal Abbreviation: Diabetes

ISSN: 0012-1797

DAY: 7

MONTH: 02

YEAR: 2007

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372763

Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Keywords Mesh Terms:

KEYWORDS: Viscera

MESH TERMS: secretion

Chemical & Substance for Abstract: Visceral fat adipokine secretion is associated with systemic inflammation in obese humans. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Visceral fat adipokine secretion is associated with systemic inflammation in obese humans.

AFFILIATION: Washington University School of Medicine, Campus Box 8031, 660 South Euclid Ave., St. Louis, MO 63110, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR-00036

ACRONYM: RR

MEDLINETA: Diabetes

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