Viral strategies for intracellular trafficking: motors and microtubules.

Viral strategies for intracellular trafficking: motors and microtubules. Research Abstract Details 

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Viral strategies for intracellular trafficking: motors and microtubules. Abstract Text:

Philip L Leopold,K Kevin Pfister,

To overcome barriers to diffusion, many viruses utilize the microtubule-associated molecular motor cytoplasmic dynein 1 to drive transport towards the nucleus of a target cell. Cytoplasmic dynein 1 generates movement towards the minus end of microtubules located at the microtubule organizing centre (MTOC), a structure that is typically in close proximity to the nucleus. Physiological cargoes for cytoplasmic dynein include membranous organelles, protein complexes and aggregates of misfolded protein. In this review, we discuss the study of microtubule-based translocation of viruses and raise questions about the mechanisms for association with and then dissociation from cytoplasmic dynein with a goal of understanding whether viruses are seen by the intracellular trafficking machinery as functional protein complexes or misfolded protein aggregates.

Viral strategies for intracellular trafficking: motors and microtubules. Publishing Authors By Initials

PL Leopold,KK Pfister,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology research

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Viral strategies for intracellular trafficking: motors and microtubules. Journal Published:

PUBLICATION TYPE: Review

Journal: Traffic (Copenhagen, Denmark)

VOLUME: 7

Page Numbers: 516-23

Journal Abbreviation: Traffic

ISSN: 1398-9219

DAY: 3

MONTH: May

YEAR: 2006

Viral strategies for intracellular trafficking: motors and microtubules. Information

Number of References: 56

LANGUAGE: eng

NlmUniqueID: 100939340

Viral strategies for intracellular trafficking: motors and microtubules. Keywords Mesh Terms:

KEYWORDS: Viral Physiology

MESH TERMS: physiology

Chemical & Substance for Abstract: Viral strategies for intracellular trafficking: motors and microtubules. Information

Substance Name: Molecular Motor Proteins

Registry Number: 0

Grant and Affiliation Information for Viral strategies for intracellular trafficking: motors and microtubules.

AFFILIATION: Department of Genetic Medicine, Weill Medical College of Cornell University, New York, NY, USA. pleopold@med.cornell.edu

Country: Denmark

AGENCY: United States PHS

GRANT: R01 ND29996

ACRONYM: HL

MEDLINETA: Traffic

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