Viral factors associated with cytokine expression during HCV/HIV co-infection.

Viral factors associated with cytokine expression during HCV/HIV co-infection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Viral factors associated with cytokine expression during HCV/HIV co-infection. Abstract Text:

Jason T Blackard,Minhee Kang,J Benjamin St Clair,Wenyu Lin,Yoshitaka Kamegaya,Kenneth E Sherman,Margaret James Koziel,Marion G Peters,Janet Andersen,Raymond T Chung, ,

Co-infection with human immunodeficiency virus (HIV) is associated with reduced hepatitis C virus (HCV) treatment response and accelerated HCV disease. Cytokines, as mediators of immune responses, inflammation, and fibrogenesis, may underlie important differences in HCV pathogenesis during HIV co-infection. We previously found that serum interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha) increased after HCV therapy with interferon (IFN) in HCV/HIV co-infected patients; however, cytokine levels were not predictive of HCV therapeutic response. Here, we examined viral factors associated with expression of IL-8, TNF-alpha, and transforming growth factor-beta1 (TGF-beta1) in uninfected, HCV mono-infected, HIV mono-infected, and HCV/HIV co-infected persons. HIV co-infection was associated with decreased IL-8 detection but not TNF-alpha detection. A significant interaction effect demonstrated that HIV infection was associated with elevated TGF-beta1 in HCV-positive individuals but not in HCV-negative individuals. The induction of a sustained profibrotic signal, such as TGF-beta1, by HIV may cause accelerated liver fibrosis during HCV/HIV co-infection and may hinder the host's ability to mount an effective HCV-specific immune response. Further studies are warranted to identify noninvasive markers of liver disease for the clinical management of HCV disease, particularly when liver biopsies have not been performed or are contraindicated.

Viral factors associated with cytokine expression during HCV/HIV co-infection. Publishing Authors By Initials

JT Blackard,M Kang,JB St Clair,W Lin,Y Kamegaya,KE Sherman,MJ Koziel,MG Peters,J Andersen,RT Chung, ,

For similar viruses research abstracts see: viruses research

PUBMED ID PMID:

MEDLINE DATE:

Viral factors associated with cytokine expression during HCV/HIV co-infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of interferon & cytokine research : the of

VOLUME: 27

Page Numbers: 263-9

Journal Abbreviation:

ISSN: 1079-9907

DAY: 3

MONTH: Apr

YEAR: 2007

Viral factors associated with cytokine expression during HCV/HIV co-infection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9507088

Viral factors associated with cytokine expression during HCV/HIV co-infection. Keywords Mesh Terms:

KEYWORDS: Viruses

MESH TERMS: metabolism

Chemical & Substance for Abstract: Viral factors associated with cytokine expression during HCV/HIV co-infection. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Viral factors associated with cytokine expression during HCV/HIV co-infection.

AFFILIATION: Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA

Country: United States

AGENCY: United States NIAID

GRANT: P30-AI42851

ACRONYM: AI

MEDLINETA: J Interferon Cytokine Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Viral factors associated with cytokine expression during HCV/HIV co-infection Related Publications

• A 2-year open-label study of galantamine therapy in Chinese Alzheimer's disease patients in Hong Kong.
• Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis.
• Characterization of a core binding site for ADAMTS-13 in the A2 domain of von Willebrand factor.
• Distribution of respiratory mucin proteins in human nasal mucosa.
• Effect of superoxide dismutase on the development of preimplantation mouse embryos.
• Estrogens and antiestrogens as etiological factors and therapeutics for prostate cancer.
• Experience of Middle- and Old-Aged Women's Aging.
• Expression of MUC5AC and MUC5B mucins in normal and cystic fibrosis lung.
• Expression of respiratory mucins in fatal status asthmaticus and mild asthma.
• Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.
• IGF-1 protects intestinal epithelial cells from oxidative stress-induced apoptosis.
• Importance of hyperexcitability of DRG neurons in neuropathic pain.
• Improved results using extensively coated THA stems at minimum 5-year followup.
• Inhibition of transforming growth factor-beta/Smad signaling by phosphatidylinositol 3-kinase pathway.
• MYCN silencing induces differentiation and apoptosis in human neuroblastoma cells.
• Mucus and fatal asthma.
• Oxidative stress induces ADAM9 protein expression in human prostate cancer cells.
• Oxidative stress-induced intestinal epithelial cell apoptosis is mediated by p38 MAPK.
• Pellegrini-Stieda disease: a heterogeneous disorder not synonymous with ossification/calcification of the tibial collateral ligament-anatomic and imaging investigation.
• Postnatal depression: an update.
• Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.
• The WPA Regional Meeting "Science and Humanism" (Seoul, April 18-21, 2007).
• The clinical implementation of respiratory-gated intensity-modulated radiotherapy.
• The role of reactive oxygen species (ROS) in persistent pain.
• Using the PHQ-9 for depression screening and treatment monitoring for Chinese Americans in primary care.
• Vanadium-catalyzed addition of propargyl alcohols and imines.
• [Development of a critical thinking disposition scale for nursing students]
• [Massive gastric ulcer bleeding in a healthy full term infant]
• [Modulation of tropoelastin expression in cultured human dermal fibroblasts by heat shock.]
• [Resistance to adefovir in patients with chronic hepatitis B]