Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Research Abstract Details 

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Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Abstract Text:

Shu Zhang,Tolga Cagatay,Manami Amanai,Mei Zhang,Janine Kline,Diego H Castrillon,Raheela Ashfaq,Orhan K Oz,Keith A Wharton,

Gradients of Wnt/beta-catenin signaling coordinate development and physiological homeostasis in metazoan animals. Proper embryonic development of the fruit fly Drosophila melanogaster requires the Naked cuticle (Nkd) protein to attenuate a gradient of Wnt/beta-catenin signaling across each segmental anlage. Nkd inhibits Wnt signaling by binding the intracellular protein Dishevelled (Dsh). Mice and humans have two nkd homologs, nkd1 and nkd2, whose encoded proteins can bind Dsh homologs (the Dvl proteins) and inhibit Wnt signaling. To determine whether nkd genes are necessary for murine development, we replaced nkd exons that encode Dvl-binding sequences with IRES-lacZ/neomycin cassettes. Mutants homozygous for each nkd(lacZ) allele are viable with slightly reduced mean litter sizes. Surprisingly, double-knockout mice are viable, with subtle alterations in cranial bone morphology that are reminiscent of mutation in another Wnt/beta-catenin antagonist, axin2. Our data show that nkd function in the mouse is dispensable for embryonic development.

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Publishing Authors By Initials

S Zhang,T Cagatay,M Amanai,M Zhang,J Kline,DH Castrillon,R Ashfaq,OK Oz,KA Wharton,

For similar peptides: intercellular signaling peptides and proteins: wnt proteins research abstracts see: peptides: intercellular signaling peptides and proteins: wnt proteins research

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Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 4454-64

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 0270-7306

DAY: 16

MONTH: 04

YEAR: 2007

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Keywords Mesh Terms:

KEYWORDS: Wnt Proteins

MESH TERMS: antagonists & inhibitors

Chemical & Substance for Abstract: Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2. Information

Substance Name: dishevelled proteins

Registry Number: 0

Grant and Affiliation Information for Viable mice with compound mutations in the Wnt/Dvl pathway antagonists nkd1 and nkd2.

AFFILIATION: Laboratory of Molecular Pathology, Department of Pathology, Dallas, TX 75390-9072, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01 GM65404

ACRONYM: GM

MEDLINETA: Mol Cell Biol

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